Topiramate, carbamazepine and valproate monotherapy: double-blind comparison in newly diagnosed epilepsy.
In: Acta Neurologica Scandinavica, Jg. 107 (2003-03-01), Heft 3, S. 165-175
Online
academicJournal
Zugriff:
Objectives – To compare topiramate (TPM) with investigator's choice of carbamazepine (CBZ) or valproate (VPA) for initial treatment in patients with newly diagnosed epilepsy. Material and methods – In patients with epilepsy diagnosed within previous 3 months, investigators selected CBZ (600 mg/day) or VPA (1250 mg/day) as preferred therapy based on the patient's clinical presentation. Based on investigators’ treatment choice, patients (n =613) were assigned to the CBZ or VPA treatment branch. Within each branch, patients were randomized to double-blind treatment with the traditional antiepileptic drugs (CBZ or VPA), TPM 100 mg/day, or TPM 200 mg/day. Patients continued double-blind treatment until exiting the study or until 6 months after last patient randomized. Results – No statistically significant differences between fixed doses of TPM and CBZ or VPA were observed in efficacy measures: time to exit, time to first seizure, and the proportion of patients seizure-free during the last 6 months of treatment. TPM 100 mg/day was associated with the fewest discontinuations due to adverse events. Conclusion – In patients with newly diagnosed epilepsy, an initial target dose of TPM 100 mg/day is at least as effective as therapeutic doses of CBZ and VPA. [ABSTRACT FROM AUTHOR]
Titel: |
Topiramate, carbamazepine and valproate monotherapy: double-blind comparison in newly diagnosed epilepsy.
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Autor/in / Beteiligte Person: | Privitera, M. D. ; Brodie, M. J. ; Mattson, R. H. ; Chadwick, D. W. ; Neto, W. ; Wang, S. |
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Zeitschrift: | Acta Neurologica Scandinavica, Jg. 107 (2003-03-01), Heft 3, S. 165-175 |
Veröffentlichung: | 2003 |
Medientyp: | academicJournal |
ISSN: | 0001-6314 (print) |
DOI: | 10.1034/j.1600-0404.2003.00093.x |
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