An Airborne Transmissible Avian Influenza H5 Hemagglutinin Seen at the Atomic Level.
In: Science, Jg. 340 (2013-06-21), Heft 6139, S. 1463-1467
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academicJournal
Zugriff:
Recent studies have identified several mutations in the hemagglutinin (HA) protein that allow the highly pathogenic avian H5N1 influenza A virus to transmit between mammals by airborne route. Here, we determined the complex structures of wild-type and mutant HAs derived from an Indonesia H5N1 virus bound to either avian or human receptor sialic acid analogs. A cis/trans conformational change in the glycosidic linkage of the receptor analog was observed, which explains how the H5N1 virus alters its receptor-binding preference. Furthermore, the mutant HA possessed low affinities for both avian and human receptors. Our findings provide a structural and biophysical basis for the H5N1 adaptation to acquire human, but maintain avian, receptor-binding properties. [ABSTRACT FROM AUTHOR]
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An Airborne Transmissible Avian Influenza H5 Hemagglutinin Seen at the Atomic Level.
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Autor/in / Beteiligte Person: | Zhang, Wei ; Shi, Yi ; Lu, Xishan ; Shu, Yuelong ; Qi, Jianxun ; Gao, George F. |
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Zeitschrift: | Science, Jg. 340 (2013-06-21), Heft 6139, S. 1463-1467 |
Veröffentlichung: | 2013 |
Medientyp: | academicJournal |
ISSN: | 0036-8075 (print) |
DOI: | 10.1126/science.1236787 |
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