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Functional MRI correlates of visuospatial planning in out-patient depression and anxiety.
In: Acta Psychiatrica Scandinavica, Jg. 124 (2011-10-01), Heft 4, S. 273-284
Online
academicJournal
Zugriff:
van Tol MJ, van der Wee NJA, Demenescu LR, Nielen MMA, Aleman A, Renken R, van Buchem MA, Zitman FG, Veltman DJ. Functional MRI correlates of visuospatial planning in out-patient depression and anxiety. Objective: Major depressive disorder (MDD) has been associated with executive dysfunction and related abnormal prefrontal activity, whereas the status of executive function (EF) in frequently co-occurring anxiety disorders and in comorbid depression-anxiety is unclear. We aimed to study functional MRI correlates of (visuospatial) planning in MDD and anxiety disorders and to test for the effects of their comorbidity. Method: Functional MRI was employed during performance of a parametric Tower of London task in out-patients with MDD ( n = 65), MDD with comorbid anxiety ( n = 82) or anxiety disorders without MDD ( n = 64), and controls ( n = 63). Results: Moderately/severely depressed patients with MDD showed increased left dorsolateral prefrontal activity as a function of task load, together with subtle slowing during task execution. In mildly depressed and remitted MDD patients, in anxiety patients, and in patients with comorbid depression-anxiety, task performance was normal and no activation differences were observed. Medication use and regional brain volume were not associated with altered visuospatial planning. Conclusion: Prefrontal hyperactivation during high planning demands is not a trait characteristic, but a state characteristic of MDD without comorbid anxiety, occurring independent of SSRI use. Disturbances in planning or the related activation are probably not a feature of anxiety disorders with or without comorbid MDD, supporting the current distinction between anxiety disorders and depression. [ABSTRACT FROM AUTHOR]
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Functional MRI correlates of visuospatial planning in out-patient depression and anxiety.
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Autor/in / Beteiligte Person: | van Tol, M. J. ; van der Wee, N. J. A. ; Demenescu, L. R. ; Nielen, M. M. A. ; Aleman, A. ; Renken, R. ; van Buchem, M. A. ; Zitman, F. G. ; Veltman, D. J. |
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Zeitschrift: | Acta Psychiatrica Scandinavica, Jg. 124 (2011-10-01), Heft 4, S. 273-284 |
Veröffentlichung: | 2011 |
Medientyp: | academicJournal |
ISSN: | 0001-690X (print) |
DOI: | 10.1111/j.1600-0447.2011.01702.x |
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