Carbon Dioxide Activation at the Ni,Fe-Cluster of Anaerobic Carbon Monoxide Dehydrogenase.
In: Science, Jg. 318 (2007-11-30), Heft 5855, S. 1461-1464
Online
academicJournal
Zugriff:
Anaerobic CO dehydrogenases catalyze the reversible oxidation of CO to CO2 at a complex Ni-, Fe-, and S-containing metal center called cluster C. We report crystal structures of CO dehydrogenase II from Carboxydothermus hydrogenoformans in three different states. In a reduced state, exogenous CO2 supplied in solution is bound and reductively activated by cluster C. In the intermediate structure, CO2 acts as a bridging ligand between Ni and the asymmetrically coordinated Fe, where it completes the square-planar coordination of the Ni ion. It replaces a water/hydroxo ligand bound to the Fe ion in the other two states. The structures define the mechanism of CO oxidation and CO2 reduction at the Ni-Fe site of cluster C. [ABSTRACT FROM AUTHOR]
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Carbon Dioxide Activation at the Ni,Fe-Cluster of Anaerobic Carbon Monoxide Dehydrogenase.
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Autor/in / Beteiligte Person: | Jeoung, Jae-Hun ; Dobbek, Holger |
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Zeitschrift: | Science, Jg. 318 (2007-11-30), Heft 5855, S. 1461-1464 |
Veröffentlichung: | 2007 |
Medientyp: | academicJournal |
ISSN: | 0036-8075 (print) |
DOI: | 10.1126/science.1148481 |
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