Natural Malaria Infection in Anopheles gambiae Is Regulated by a Single Genomic Control Region.
In: Science, Jg. 312 (2006-04-28), Heft 5773, S. 577-579
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academicJournal
Zugriff:
We surveyed an Anopheles gambiae population in a West African malaria transmission zone for naturally occurring genetic loci that control mosquito infection with the human malaria parasite, Plasmodium falciparum. The strongest Plasmodium resistance loci cluster in a small region of chromosome 2L and each locus explains at least 89% of parasite-free mosquitoes in independent pedigrees. Together, the clustered loci form a genomic Plasmodium-resistance island that explains most of the genetic variation for malaria parasite infection of mosquitoes in nature. Among the candidate genes in this chromosome region, RNA interference knockdown assays confirm a role in Plasmodium resistance for Anopheles Plasmodium-responsive leucine-rich repeat 1 (APL1), encoding a leucine-rich repeat protein that is similar to molecules involved in natural pathogen resistance mechanisms in plants and mammals. [ABSTRACT FROM AUTHOR]
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Natural Malaria Infection in Anopheles gambiae Is Regulated by a Single Genomic Control Region.
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Autor/in / Beteiligte Person: | Riehle, Michelle M. ; Markianos, Kyriacos ; Niaré, Oumou ; Xu, Jiannong ; Li, Jun ; Touré, Abdoulaye M. ; Podiougou, Belco ; Oduol, Frederick ; Diawara, Sory ; Diallo, Mouctar ; Coulibaly, Boubacar ; Ouatara, Ahmed ; Kruglyak, Leonid ; Traoré, Sékou F. ; Vernick, Kenneth D. |
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Zeitschrift: | Science, Jg. 312 (2006-04-28), Heft 5773, S. 577-579 |
Veröffentlichung: | 2006 |
Medientyp: | academicJournal |
ISSN: | 0036-8075 (print) |
DOI: | 10.1126/science.1124153 |
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