Volltext verfügbar nach Anmeldung bzw. im Campus-Netz.
Investigation of the risk of valproic acid–induced tremor: clinical, neuroimaging, and genetic factors.
In: Psychopharmacology, Jg. 239 (2022), Heft 1, S. 173-184
Online
academicJournal
Zugriff:
Rationale: Investigation of associated risk factors of valproic acid (VPA)–induced tremor helped in increasing tolerance and optimizing treatment scheme individually. Objectives: To determine the risk factors of VPA-induced tremor, with particular attention on identifying tremor-susceptible gene mutations. Methods: Epileptic patients taking VPA were divided into a tremor and a non-tremor groups. A mutation of rs9652490 in the leucine-rich repeat and immunoglobulin domain-containing Nogo-receptor-interacting protein 1 (LINGO-1) gene was determined by Sanger sequencing. Cerebellar atrophy was assessed, and various cerebellar dimensions were measured on magnetic resonance imaging (MRI) scans. Results: One hundred and eighty-one of 200 subjects were included. Multivariate regression analysis indicated several VPA-induced tremor-related factors: females (OR = 2.718, p = 0.014), family history of tremor (OR = 7.595, p = 0.003), treatment duration (> 24 months; OR = 3.294, p = 0.002), and daily dosage (> 1,000 mg/d; OR = 19.801, p = 0.008) of VPA. Chi-square tests revealed that treatment with VPA magnesium-ER (p = 0.030) and carbamazepine combination (p = 0.040) reduced the incidence of tremor. One hundred and seventy-six gene sequencing and 86 MRI results excluded any significant difference between the two groups in the mutation of rs9652490 within LINGO-1, the ratio of cerebellar atrophy or the cerebellar-dimension values (p > 0.05). However, mutation of rs9652490 within LINGO-1 was correlated with increased cerebellar atrophy (p = 0.001), reduced cerebellar hemisphere thickness (p = 0.025), and right cerebellar hemisphere longitudinal diameter (p = 0.047). Conclusions: Our cohort indicated risk (female, positive family history of tremor, daily dosage > 1000 mg and treatment duration > 24 months of VPA) and protective factors (VPA magnesium-ER and combination with CBZ) of VPA-induced tremor. Mutation of rs9652490 within LINGO-1 correlated with cerebellar atrophy, neither was correlated with VPA-induced tremor. [ABSTRACT FROM AUTHOR]
Titel: |
Investigation of the risk of valproic acid–induced tremor: clinical, neuroimaging, and genetic factors.
|
---|---|
Autor/in / Beteiligte Person: | Lan, Lili ; Zhao, Xu ; Jian, Si ; Li, Cun ; Wang, Man ; Zhou, Qing ; Huang, Shanshan ; Zhu, Suiqiang ; Kang, Huicong ; Kirsch, Heidi E. |
Link: | |
Zeitschrift: | Psychopharmacology, Jg. 239 (2022), Heft 1, S. 173-184 |
Veröffentlichung: | 2022 |
Medientyp: | academicJournal |
ISSN: | 0033-3158 (print) |
DOI: | 10.1007/s00213-021-06004-5 |
Schlagwort: |
|
Sonstiges: |
|