A novel SARS-CoV-2 related coronavirus in bats from Cambodia
In: Nature Communications, Jg. 12 (2021), Heft 1
academicJournal
- 6563
Zugriff:
Knowledge of the origin and reservoir of the coronavirus responsible for the ongoing COVID-19 pandemic is still fragmentary. To date, the closest relatives to SARS-CoV-2 have been detected in Rhinolophus bats sampled in the Yunnan province, China. Here we describe the identification of SARS-CoV-2 related coronaviruses in two Rhinolophus shameli bats sampled in Cambodia in 2010. Metagenomic sequencing identifies nearly identical viruses sharing 92.6% nucleotide identity with SARS-CoV-2. Most genomic regions are closely related to SARS-CoV-2, with the exception of a region of the spike, which is not compatible with human ACE2-mediated entry. The discovery of these viruses in a bat species not found in China indicates that SARS-CoV-2 related viruses have a much wider geographic distribution than previously reported, and suggests that Southeast Asia represents a key area to consider for future surveillance for coronaviruses.
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A novel SARS-CoV-2 related coronavirus in bats from Cambodia
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Autor/in / Beteiligte Person: | Delaune, Deborah ; Hul, Vibol ; Karlsson, Erik A ; Hassanin, Alexandre ; Ou, Tey Putita ; Baidaliuk, Artem ; Gámbaro, Fabiana ; Prot, Matthieu ; Tu, Vuong Tan ; Chea, Sokha ; Keatts, Lucy ; Mazet, Jonna ; Johnson, Christine K ; Buchy, Philippe ; Dussart, Philippe ; Goldstein, Tracey ; Simon-Lorière, Etienne ; Duong, Veasna |
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Zeitschrift: | Nature Communications, Jg. 12 (2021), Heft 1 |
Veröffentlichung: | eScholarship, University of California, 2021 |
Medientyp: | academicJournal |
Umfang: | 6563 |
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