Centenarian clocks: epigenetic clocks for validating claims of exceptional longevity
In: GeroScience, Jg. 45 (2023-06-01), Heft 3
academicJournal
- 1817 - 1835
Zugriff:
Claims surrounding exceptional longevity are sometimes disputed or dismissed for lack of credible evidence. Here, we present three DNA methylation-based age estimators (epigenetic clocks) for verifying age claims of centenarians. The three centenarian clocks were developed based on n = 7039 blood and saliva samples from individuals older than 40, including n = 184 samples from centenarians, 122 samples from semi-supercentenarians (aged 105 +), and 25 samples from supercentenarians (aged 110 +). The oldest individual was 115 years old. Our most accurate centenarian clock resulted from applying a neural network model to a training set composed of individuals older than 40. An epigenome-wide association study of age in different age groups revealed that age effects in young individuals (age 90). We present a chromatin state analysis of age effects in centenarians. The centenarian clocks are expected to be useful for validating claims surrounding exceptional old age.
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Centenarian clocks: epigenetic clocks for validating claims of exceptional longevity
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Autor/in / Beteiligte Person: | Dec, Eric ; Clement, James ; Cheng, Kaiyang ; Church, George M ; Fossel, Michael B ; Rehkopf, David H ; Rosero-Bixby, Luis ; Kobor, Michael S ; Lin, David TS ; Lu, Ake T ; Fei, Zhe ; Guo, Wei ; Chew, Yap Ching ; Yang, Xiaojing ; Putra, Sulistyo E Dwi ; Reiner, Alex P ; Correa, Adolfo ; Vilalta, Adrian ; Pirazzini, Chiara ; Passarino, Giuseppe ; Monti, Daniela ; Arosio, Beatrice ; Garagnani, Paolo ; Franceschi, Claudio ; Horvath, Steve |
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Zeitschrift: | GeroScience, Jg. 45 (2023-06-01), Heft 3 |
Veröffentlichung: | eScholarship, University of California, 2023 |
Medientyp: | academicJournal |
Umfang: | 1817 - 1835 |
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