Role of Polyunsaturated Fat in Modifying Cardiovascular Risk Associated With Family History of Cardiovascular Disease: Pooled De Novo Results From 15 Observational Studies.
In: Circulation, Jg. 149 (2024-01-23), Heft 4
academicJournal
Zugriff:
BACKGROUND: It is unknown whether dietary intake of polyunsaturated fatty acids (PUFA) modifies the cardiovascular disease (CVD) risk associated with a family history of CVD. We assessed interactions between biomarkers of low PUFA intake and a family history in relation to long-term CVD risk in a large consortium. METHODS: Blood and tissue PUFA data from 40 885 CVD-free adults were assessed. PUFA levels ≤25th percentile were considered to reflect low intake of linoleic, alpha-linolenic, and eicosapentaenoic/docosahexaenoic acids (EPA/DHA). Family history was defined as having ≥1 first-degree relative who experienced a CVD event. Relative risks with 95% CI of CVD were estimated using Cox regression and meta-analyzed. Interactions were assessed by analyzing product terms and calculating relative excess risk due to interaction. RESULTS: After multivariable adjustments, a significant interaction between low EPA/DHA and family history was observed (product term pooled RR, 1.09 [95% CI, 1.02-1.16]; P=0.01). The pooled relative risk of CVD associated with the combined exposure to low EPA/DHA, and family history was 1.41 (95% CI, 1.30-1.54), whereas it was 1.25 (95% CI, 1.16-1.33) for family history alone and 1.06 (95% CI, 0.98-1.14) for EPA/DHA alone, compared with those with neither exposure. The relative excess risk due to interaction results indicated no interactions. CONCLUSIONS: A significant interaction between biomarkers of low EPA/DHA intake, but not the other PUFA, and a family history was observed. This novel finding might suggest a need to emphasize the benefit of consuming oily fish for individuals with a family history of CVD.
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Role of Polyunsaturated Fat in Modifying Cardiovascular Risk Associated With Family History of Cardiovascular Disease: Pooled De Novo Results From 15 Observational Studies.
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Autor/in / Beteiligte Person: | Brouwer, Ingeborg ; De Faire, Ulf ; Eiriksdottir, Gudny ; Ferrucci, Luigi ; Forouhi, Nita ; Geleijnse, Johanna ; Hodge, Allison ; Kimura, Hitomi ; Laakso, Markku ; Risérus, Ulf ; van Westing, Anniek ; Bandinelli, Stefania ; Baylin, Ana ; Giles, Graham ; Gudnason, Vilmundur ; Iso, Hiroyasu ; Lemaitre, Rozenn ; Ninomiya, Toshiharu ; Post, Wendy ; Psaty, Bruce ; Salonen, Jukka ; Schulze, Matthias ; Tsai, Michael ; Uusitupa, Matti ; Wareham, Nicholas ; Oh, Seung-Won ; Wood, Alexis ; Harris, William ; Siscovick, David ; Mozaffarian, Dariush ; Leander, Karin ; Laguzzi, Federica ; Åkesson, Agneta ; Marklund, Matti ; Qian, Frank ; Gigante, Bruna ; Bartz, Traci ; Bassett, Julie ; Birukov, Anna ; Campos, Hannia ; Hirakawa, Yoichiro ; Imamura, Fumiaki ; Jäger, Susanne ; Lankinen, Maria ; Murphy, Rachel ; Senn, Mackenzie ; Tanaka, Toshiko ; Tintle, Nathan ; Virtanen, Jyrki ; Yamagishi, Kazumasa ; Allison, Matthew |
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Zeitschrift: | Circulation, Jg. 149 (2024-01-23), Heft 4 |
Veröffentlichung: | eScholarship, University of California, 2024 |
Medientyp: | academicJournal |
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