Raltegravir versus efavirenz in antiretroviral-naive pregnant women living with HIV (NICHD P1081): an open-label, randomised, controlled, phase 4 trial
In: The Lancet HIV, Jg. 7 (2020-05-01), Heft 5
academicJournal
- e322 - e331
Zugriff:
BackgroundAlthough antiretroviral regimens containing integrase inhibitors rapidly suppress HIV viral load in non-pregnant adults, few published data from randomised controlled trials have compared the safety and efficacy of any integrase inhibitor to efavirenz when initiated during pregnancy. We compared safety and efficacy of antiretroviral therapy with either raltegravir or efavirenz in late pregnancy.MethodsAn open-label, randomised controlled trial was done at 19 hospitals and clinics in Argentina, Brazil, South Africa, Tanzania, Thailand, and the USA. Antiretroviral-naive pregnant women (20-
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Raltegravir versus efavirenz in antiretroviral-naive pregnant women living with HIV (NICHD P1081): an open-label, randomised, controlled, phase 4 trial
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Autor/in / Beteiligte Person: | João, Esaú C ; Morrison, R Leavitt ; Shapiro, David E ; Chakhtoura, Nahida ; Gouvèa, Maria Isabel S ; de Lourdes B Teixeira, Maria ; Fuller, Trevon L ; Mmbaga, Blandina T ; Ngocho, James S ; Njau, Boniface N ; Violari, Avy ; Mathiba, Ruth ; Essack, Zaynab ; Pilotto, Jose Henrique S ; Moreira, Luis Felipe ; Rolon, Maria Jose ; Cahn, Pedro ; Prommas, Sinart ; Cressey, Timothy R ; Chokephaibulkit, Kulkanya ; Werarak, Peerawong ; Laimon, Lauren ; Hennessy, Roslyn ; Frenkel, Lisa M ; Anthony, Patricia ; Best, Brookie M ; Siberry, George K ; Mirochnick, Mark |
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Zeitschrift: | The Lancet HIV, Jg. 7 (2020-05-01), Heft 5 |
Veröffentlichung: | eScholarship, University of California, 2020 |
Medientyp: | academicJournal |
Umfang: | e322 - e331 |
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