New genetic loci link adipose and insulin biology to body fat distribution
In: Nature, Jg. 518 (2015-02-12), Heft 7538
academicJournal
- 187 - 196
Zugriff:
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P
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New genetic loci link adipose and insulin biology to body fat distribution
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| Autor/in / Beteiligte Person: | Shungin, Dmitry ; Winkler, Thomas W ; Croteau-Chonka, Damien C ; Ferreira, Teresa ; Locke, Adam E ; Mägi, Reedik ; Strawbridge, Rona J ; Pers, Tune H ; Fischer, Krista ; Justice, Anne E ; Workalemahu, Tsegaselassie ; Wu, Joseph MW ; Buchkovich, Martin L ; Heard-Costa, Nancy L ; Roman, Tamara S ; Drong, Alexander W ; Song, Ci ; Gustafsson, Stefan ; Day, Felix R ; Esko, Tonu ; Fall, Tove ; Kutalik, Zoltán ; Luan, Jian’an ; Randall, Joshua C ; Scherag, André ; Vedantam, Sailaja ; Wood, Andrew R ; Chen, Jin ; Fehrmann, Rudolf ; Karjalainen, Juha ; Kahali, Bratati ; Liu, Ching-Ti ; Schmidt, Ellen M ; Absher, Devin ; Amin, Najaf ; Anderson, Denise ; Beekman, Marian ; Bragg-Gresham, Jennifer L ; Buyske, Steven ; Demirkan, Ayse ; Ehret, Georg B ; Feitosa, Mary F ; Goel, Anuj ; Jackson, Anne U ; Johnson, Toby ; Kleber, Marcus E ; Kristiansson, Kati ; Mangino, Massimo ; Mateo Leach, Irene ; Medina-Gomez, Carolina ; Palmer, Cameron D ; Pasko, Dorota ; Pechlivanis, Sonali ; Peters, Marjolein J ; Prokopenko, Inga ; Stančáková, Alena ; Ju Sung, Yun ; Tanaka, Toshiko ; Teumer, Alexander ; Van Vliet-Ostaptchouk, Jana V ; Yengo, Loïc ; Zhang, Weihua ; Albrecht, Eva ; Ärnlöv, Johan ; Arscott, Gillian M ; Bandinelli, Stefania ; Barrett, Amy ; Bellis, Claire ; Bennett, Amanda J ; Berne, Christian ; Blüher, Matthias ; Böhringer, Stefan ; Bonnet, Fabrice ; Böttcher, Yvonne ; Bruinenberg, Marcel ; Carba, Delia B ; Caspersen, Ida H ; Clarke, Robert ; Warwick Daw, E ; Deelen, Joris ; Deelman, Ewa ; Delgado, Graciela ; Doney, Alex SF ; Eklund, Niina ; Erdos, Michael R ; Estrada, Karol ; Eury, Elodie ; Friedrich, Nele ; Garcia, Melissa E ; Giedraitis, Vilmantas ; Gigante, Bruna ; Go, Alan S ; Golay, Alain ; Grallert, Harald ; Grammer, Tanja B ; Gräßler, Jürgen ; Grewal, Jagvir ; Groves, Christopher J ; Haller, Toomas ; Hallmans, Goran |
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| Zeitschrift: | Nature, Jg. 518 (2015-02-12), Heft 7538 |
| Veröffentlichung: | eScholarship, University of California, 2015 |
| Medientyp: | academicJournal |
| Umfang: | 187 - 196 |
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