Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.
In: Nature genetics, Jg. 43 (2011-05-01), Heft 5
academicJournal
- 436 - 441
Zugriff:
The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association study of late-onset Alzheimer disease using a three-stage design consisting of a discovery stage (stage 1) and two replication stages (stages 2 and 3). Both joint analysis and meta-analysis approaches were used. We obtained genome-wide significant results at MS4A4A (rs4938933; stages 1 and 2, meta-analysis P (P(M)) = 1.7 × 10(-9), joint analysis P (P(J)) = 1.7 × 10(-9); stages 1, 2 and 3, P(M) = 8.2 × 10(-12)), CD2AP (rs9349407; stages 1, 2 and 3, P(M) = 8.6 × 10(-9)), EPHA1 (rs11767557; stages 1, 2 and 3, P(M) = 6.0 × 10(-10)) and CD33 (rs3865444; stages 1, 2 and 3, P(M) = 1.6 × 10(-9)). We also replicated previous associations at CR1 (rs6701713; P(M) = 4.6 × 10(-10), P(J) = 5.2 × 10(-11)), CLU (rs1532278; P(M) = 8.3 × 10(-8), P(J) = 1.9 × 10(-8)), BIN1 (rs7561528; P(M) = 4.0 × 10(-14), P(J) = 5.2 × 10(-14)) and PICALM (rs561655; P(M) = 7.0 × 10(-11), P(J) = 1.0 × 10(-10)), but not at EXOC3L2, to late-onset Alzheimer's disease susceptibility.
| Titel: |
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.
|
|---|---|
| Autor/in / Beteiligte Person: | Naj, Adam C ; Jun, Gyungah ; Beecham, Gary W ; Wang, Li-San ; Vardarajan, Badri Narayan ; Buros, Jacqueline ; Gallins, Paul J ; Buxbaum, Joseph D ; Jarvik, Gail P ; Crane, Paul K ; Larson, Eric B ; Bird, Thomas D ; Boeve, Bradley F ; Graff-Radford, Neill R ; De Jager, Philip L ; Evans, Denis ; Schneider, Julie A ; Carrasquillo, Minerva M ; Ertekin-Taner, Nilufer ; Younkin, Steven G ; Cruchaga, Carlos ; Kauwe, John SK ; Nowotny, Petra ; Kramer, Patricia ; Hardy, John ; Huentelman, Matthew J ; Myers, Amanda J ; Barmada, Michael M ; Demirci, F Yesim ; Baldwin, Clinton T ; Green, Robert C ; Rogaeva, Ekaterina ; St George-Hyslop, Peter ; Arnold, Steven E ; Barber, Robert ; Beach, Thomas ; Bigio, Eileen H ; Bowen, James D ; Boxer, Adam ; Burke, James R ; Cairns, Nigel J ; Carlson, Chris S ; Carney, Regina M ; Carroll, Steven L ; Chui, Helena C ; Clark, David G ; Corneveaux, Jason ; Cotman, Carl W ; Cummings, Jeffrey L ; DeCarli, Charles ; DeKosky, Steven T ; Diaz-Arrastia, Ramon ; Dick, Malcolm ; Dickson, Dennis W ; Ellis, William G ; Faber, Kelley M ; Fallon, Kenneth B ; Farlow, Martin R ; Ferris, Steven ; Frosch, Matthew P ; Galasko, Douglas R ; Ganguli, Mary ; Gearing, Marla ; Geschwind, Daniel H ; Ghetti, Bernardino ; Gilbert, John R ; Gilman, Sid ; Giordani, Bruno ; Glass, Jonathan D ; Growdon, John H ; Hamilton, Ronald L ; Harrell, Lindy E ; Head, Elizabeth ; Honig, Lawrence S ; Hulette, Christine M ; Hyman, Bradley T ; Jicha, Gregory A ; Jin, Lee-Way ; Johnson, Nancy ; Karlawish, Jason ; Karydas, Anna ; Kaye, Jeffrey A ; Kim, Ronald ; Koo, Edward H ; Kowall, Neil W ; Lah, James J ; Levey, Allan I ; Lieberman, Andrew P ; Lopez, Oscar L ; Mack, Wendy J ; Marson, Daniel C ; Martiniuk, Frank ; Mash, Deborah C ; Masliah, Eliezer ; McCormick, Wayne C ; McCurry, Susan M ; McDavid, Andrew N ; McKee, Ann C ; Mesulam, Marsel ; Miller, Bruce L |
| Link: | |
| Zeitschrift: | Nature genetics, Jg. 43 (2011-05-01), Heft 5 |
| Veröffentlichung: | eScholarship, University of California, 2011 |
| Medientyp: | academicJournal |
| Umfang: | 436 - 441 |
| Schlagwort: |
|
| Sonstiges: |
|