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Application of carbon-based nanomaterial in the preparation of drug for alleviating or treating HD. The carbon-based nanomaterial was prepared from the vitamin or quasi-vitamins.

Titel:	APPLICATION OF CARBON-BASED NANOMATERIAL IN PREPARATION OF DRUG FOR RELIEVING OR TREATING HD
Link:	Zum Volltext
Veröffentlichung:	2022
Medientyp:	Patent
Sonstiges:	Nachgewiesen in: USPTO Patent Applications Sprachen: English Document Number: 20220249548 Publication Date: August 11, 2022 Appl. No: 17/627810 Application Filed: July 17, 2020 Claim: 1. An application in the preparation of mHtt aggregation inhibitors or mHtt scavengers; or application of carbon-based nanomaterial in the preparation of drugs for the treatment or alleviation of HD; or application of carbon-based nanomaterial in the removal of mHtt or the inhibition of mHtt aggregation; wherein the carbon-based nanomaterial is prepared from vitamins or quasi-vitamins. Claim: 2. According to the application of claim 1, wherein the carbon-based nanomaterial is prepared by heating reaction between vitamins or quasi-vitamins. Claim: 3. According to the application of claim 2, wherein the vitamin solution or the quasi-vitamins solution undergoes heating reaction to prepare carbon-based nanomaterial; the concentration of the vitamin solution is 0.1 g/mL; the concentration of the quasi-vitamins solution is 0.1 g/mL. Claim: 4. According to the application of claim 2, wherein the heating reaction is at 170° C. to 190° C., for 1.5 h to 2.5 h. Claim: 5. According to the application of claim 2, wherein after heating reaction, naturally cooled to room temperature, and filtered; then the filtrate is dialyzed and lyophilization to obtain the carbon-based nanomaterial. Claim: 6. According to the application of claim 5, wherein dialysis with 500 to 1000 Da dialysis bag in water; the lyophilization is freezing at −80° C. for 2 h, and then lyophilization at −80° Cwith vacuum of 10 Pa for 48 h. Claim: 7. A drug for inhibiting mHtt aggregation or treating HD, wherein comprising the carbon-based nanomaterial; the carbon-based nanomaterial is prepared by heating a vitamin solution or quasi-vitamins solution; the concentration of the vitamin solution is 0.1 g/mL; the concentration of the quasi-vitamins solution is 0.1 g/mL. Claim: 8. According to the drug of claim 7, wherein the drug is the aqueous solution of carbon-based nanomaterial. Claim: 9. A method for inhibiting the aggregation of mHtt, wherein comprises the follow steps, the aqueous solution of carbon-based nanomaterials and mHtt monomers are incubated to achieve the inhibition of mHtt aggregation. Claim: 10. According to the method for inhibiting mHtt aggregation of claim 9, wherein the vitamin solution or the quasi-vitamins solution undergoes heating reaction to prepare carbon-based nanomaterial; the concentration of the vitamin solution is 0.1 g/mL; the concentration of the quasi-vitamins solution is 0.1 g/mL. Current International Class: 61

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APPLICATION OF CARBON-BASED NANOMATERIAL IN PREPARATION OF DRUG FOR RELIEVING OR TREATING HD