Modulation of Pain by Endocannabinoids in the Periphery
2020., 2020
Online
unknown
Zugriff:
Activation of cannabinoid receptors using systemic treatments produces analgesia in a variety of experimental pain models, but these effects are hindered by sedation and motor impairment mediated by receptors in the central nervous system. Targeting the endocannabinoid system in the periphery can bypass these unwanted side effects while still producing analgesia in both acute and chronic pain states. This chapter discusses the different approaches to increasing peripheral endocannabinoid activity in experimental models of acute and chronic pain, including inflammatory pain, neuropathic pain, and sickle cell disease. We also explore how these treatments alter nociceptive activity in the peripheral nervous system.
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Modulation of Pain by Endocannabinoids in the Periphery
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Autor/in / Beteiligte Person: | Uhelski, Megan ; Simone, Donald ; Khasabova, Iryna |
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Veröffentlichung: | 2020., 2020 |
Medientyp: | unknown |
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