Novel haemodialysis (HD) treatment employing molecular hydrogen (H2)-enriched dialysis solution improves prognosis of chronic dialysis patients: A prospective observational study
In: Scientific Reports, Jg. 8 (2018), Heft 1, S. 1-10
Online
academicJournal
Zugriff:
Abstract Recent studies have revealed unique biological characteristics of molecular hydrogen (H2) as an anti-inflammatory agent. We developed a novel haemodialysis (E-HD) system delivering an H2 (30–80 ppb)-enriched dialysis solution by water electrolysis, and conducted a non-randomized, non-blinded, prospective observational study exploring its clinical impact. Prevalent chronic HD patients were allocated to either the E-HD (n = 161) group or the conventional HD (C-HD: n = 148) group, and received the respective HD treatments during the study. The primary endpoint was a composite of all-cause mortality and development of non-lethal cardio-cerebrovascular events (cardiac disease, apoplexy, and leg amputation due to peripheral artery disease). During the 3.28-year mean observation period, there were no differences in dialysis parameters between the two groups; however, post-dialysis hypertension was ameliorated with significant reductions in antihypertensive agents in the E-HD patients. There were 91 events (50 in the C-HD group and 41 in the E-HD group). Multivariate analysis of the Cox proportional hazards model revealed E-HD as an independent significant factor for the primary endpoint (hazard ratio 0.59; [95% confidence interval: 0.38–0.92]) after adjusting for confounding factors (age, cardiovascular disease history, serum albumin, and C-reactive protein). HD applying an H2-dissolved HD solution could improve the prognosis of chronic HD patients.
Titel: |
Novel haemodialysis (HD) treatment employing molecular hydrogen (H2)-enriched dialysis solution improves prognosis of chronic dialysis patients: A prospective observational study
|
---|---|
Autor/in / Beteiligte Person: | Nakayama, Masaaki ; Itami, Noritomo ; Suzuki, Hodaka ; Hamada, Hiromi ; Yamamoto, Ryo ; Tsunoda, Kazumasa ; Osaka, Naoyuki ; Nakano, Hirofumi ; Maruyama, Yukio ; Kabayama, Shigeru ; Nakazawa, Ryoichi ; Miyazaki, Mariko ; Ito, Sadayoshi |
Link: | |
Zeitschrift: | Scientific Reports, Jg. 8 (2018), Heft 1, S. 1-10 |
Veröffentlichung: | Nature Portfolio, 2018 |
Medientyp: | academicJournal |
ISSN: | 2045-2322 (print) |
DOI: | 10.1038/s41598-017-18537-x |
Schlagwort: |
|
Sonstiges: |
|