What is the aetiology of dysnatraemia in COVID-19 and how is this related to outcomes in patients admitted during earlier and later COVID-19 waves? A multicentre, retrospective observational study in 11 Dutch hospitals
In: BMJ Open, Jg. 13 (2023-11-01), Heft 11
Online
academicJournal
Zugriff:
Objectives To evaluate the relationship among dysnatraemia at hospital presentation and duration of admission, risk of intensive care unit (ICU) admission and all-cause mortality and to assess the underlying pathophysiological mechanism of hyponatraemia in patients with COVID-19. Our hypothesis is that both hyponatraemia and hypernatraemia at presentation are associated with adverse outcomes.Design Observational study.Setting Secondary care; 11 Dutch hospitals (2 university and 9 general hospitals).Participants An analysis was performed within the retrospective multicentre cohort study COVIDPredict. 7811 patients were included (60% men, 40% women) between 24 February 2020 and 9 August 2022. Patients who were ≥18 years with PCR-confirmed COVID-19 or CT with COVID-19 reporting and data system score≥4 and alternative diagnosis were included. Patients were excluded when serum sodium levels at presentation were not registered in the database or when they had been transferred from another participating hospital.Outcome measures We studied demographics, medical history, symptoms and outcomes. Patients were stratified according to serum sodium concentration and urinary sodium excretion.Results Hyponatraemia was present in 2677 (34.2%) patients and hypernatraemia in 126 (1.6%) patients. Patients with hyponatraemia presented more frequently with diarrhoea, lower blood pressure and tachycardia. Hyponatraemia was, despite a higher risk for ICU admission (OR 1.27 (1.11–1.46; p
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What is the aetiology of dysnatraemia in COVID-19 and how is this related to outcomes in patients admitted during earlier and later COVID-19 waves? A multicentre, retrospective observational study in 11 Dutch hospitals
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Autor/in / Beteiligte Person: | Verkouteren, Babette ; Piña-Fuentes, Dan ; Beudel, Martijn ; Ludden, Thomas ; Rik H G Olde Engberink ; Dormans, Tom ; Martijn D de Kruif ; Simsek, Suat ; Joop P van den Bergh ; Moeniralam, Hazra ; Douma, Renee ; Brinkman, Kees ; Hinsenveld, Wouter ; Ramos, Lucas ; Pirson, Anne ; Hubers, Deborah ; Hu, Shi ; Thomas, Rajat ; Schinkel, Michiel ; Caroline E Wyers ; Rusch, Daisy ; Lianne de Haan ; Niels C Gritters van den Oever ; Paternotte, Nienke ; Goldhoorn, Robert-Jan ; Appelman, Brent ; Lems, Esther ; Marije ten Wolde ; Esther K Haspels-Hogervorst ; Bokhizzou, Neyma ; Niels Gritters van den Oever ; Joop van den Bergh ; Martijn de Kruif ; Leavis, Helen ; Arts, Derk ; Nurmohamed, Nick ; Reeskamp, Rens ; Herter, Willem ; Vonk, Bas ; Lopes, Ricardo ; Huberts, Deborah ; Wolfers, Marije ; Sander de Kuij ; Noordzij, Sophie ; Sibbeliene van den Bosch ; Verhoef, Benthe ; Methorst, Michele ; Darwesh, Shahan ; Tijn van Egmond ; Nasim, Gulsum ; Ali, Hamza ; Lars de Boer ; Nagel, Myrthe ; Koenis, Maud ; Bijlsma, Agnetha ; Balvers, Britt ; Ghauharali, Isabella ; Jelle de Jongh ; Emanuel, Maira ; Aynaou, Nisrine ; Rosemarie de Ridder ; Darraz, Insaff ; Darraz, Oumaima ; Cinar, Alanar ; Roosen, Jesse ; Heideman, Larissa ; Leliveld, Asabi ; Ruijter, Dana ; Rosenberg, Neeltje ; Woutman, Djoeke ; Vermeulen, Tom ; Sam de Joode ; Berger, Willem ; Varan, Ozgu ; Pinto, Soesja ; Sluis, Sientje ; Kuiper, Bibi ; Tim van der Putten ; Bosje, Dominique ; Sinyangwe, Mahunda ; Roos van Rhijn ; Kruif, Koen ; Miriam den Heijer ; Koen de Kruijf ; Hofhuis, Sam ; Telting, Gwendolyn ; Susan van der Lei ; Pien van Paassen ; Emil ter Veer ; Opschoor, Krijna ; Breukhoven, Camille ; Jiwa, Florine ; Peter de Gooyer ; Vrijdag, Jan ; Stans van Gelder ; Pannekoek, Anne ; Dommershuijzen, Laura ; Adang, Estelle ; Maud van Maren ; Koop, Isabel ; Sanders, Bart ; Wanten, Joukje ; Trommelen, Dax ; Smeets, Fleur ; Heuvelings, Kyra ; Cox, Maud ; Rademaekers, Milou ; Hendrikx, Vivian ; Ilona van Rooij ; Heuts, Wendy ; Oudeman, Laura ; Brans, Evelien ; Slot, Karin ; Boerma-Argelo, Kirsten ; Kok, Wilma ; Harmsen, Lieke ; Boerema, Ingrid ; Raafs, Anne ; Smaal, Anne ; Pop, Bibiane ; Waterink, Carmen ; Vrij, Casper ; Daphne van der Willik ; Reitsma, Frederic ; Pieters, Imogene ; Logger, Jade ; Sijben, Laura ; Peeters, Maikel ; Teunissen, Mariël ; Blok-Hoos, Marije ; Ketels, Marjolein ; Henkens, Michiel ; Spanjers, Mireille ; Jacob-Dols, Monique ; Patrick de Hoogt ; Houben, Rik ; Roos van Gorp ; Jansen, Josien |
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Zeitschrift: | BMJ Open, Jg. 13 (2023-11-01), Heft 11 |
Veröffentlichung: | BMJ Publishing Group, 2023 |
Medientyp: | academicJournal |
ISSN: | 2044-6055 (print) |
DOI: | 10.1136/bmjopen-2023-075232 |
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