Structural and functional characterization of NEMO cleavage by SARS-CoV-2 3CLpro
In: Nature Communications, Jg. 13 (2022), Heft 1, S. 1-15
Online
academicJournal
Zugriff:
The authors report crystallographic and computational studies that detail how SARS-CoV-2 3CLpro cleaves the host NF-κB Essential Modulator in addition to its canonical viral substrates. The association with the high fitness of SARS-CoV-2 in humans is discussed.
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Structural and functional characterization of NEMO cleavage by SARS-CoV-2 3CLpro
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Autor/in / Beteiligte Person: | Hameedi, Mikhail A. ; Prates, Erica T. ; Garvin, Michael R. ; Mathews, Irimpan I. ; B. Kirtley Amos ; Demerdash, Omar ; Bechthold, Mark ; Iyer, Mamta ; Rahighi, Simin ; Kneller, Daniel W. ; Kovalevsky, Andrey ; Irle, Stephan ; Vuong, Van-Quan ; Mitchell, Julie C. ; Labbe, Audrey ; Galanie, Stephanie ; Wakatsuki, Soichi ; Jacobson, Daniel |
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Zeitschrift: | Nature Communications, Jg. 13 (2022), Heft 1, S. 1-15 |
Veröffentlichung: | Nature Portfolio, 2022 |
Medientyp: | academicJournal |
ISSN: | 2041-1723 (print) |
DOI: | 10.1038/s41467-022-32922-9 |
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