Urate crystal deposition is associated with inflammatory markers and carotid artery pathology in patients with intercritical gout: results from the NOR-Gout study
In: RMD Open, Jg. 8 (2022-11-01), Heft 2
Online
academicJournal
Zugriff:
Background Gout is of unknown reason associated with cardiovascular disease. Ultrasound is sensitive for detecting crystal deposition and plasma calprotectin is a sensitive inflammatory marker. This study explores the associations between crystal deposition, inflammation and carotid artery pathology.Method A cross-sectional analysis of baseline assessments from the NOR-Gout study was undertaken. Crystal deposition was assessed by ultrasound (double contour, tophi, aggregates) and dual-energy CT (DECT) and laboratory assessments included plasma calprotectin. The carotid arteries were bilaterally examined for carotid intima–media thickness (cIMT) and presence of plaques. Spearman correlations, Mann-Whitney tests and linear regression analyses were used to explore associations between crystal deposition, inflammatory markers,and carotid pathology.Results 202 patients with intercritical gout (95.5% men, mean (SD) age 56.5 (13.8) years, disease duration 7.9 (7.7) years) were included. Calprotectin was correlated with all scores of crystal deposition by ultrasound (r=0.26–0.32, p
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Urate crystal deposition is associated with inflammatory markers and carotid artery pathology in patients with intercritical gout: results from the NOR-Gout study
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Autor/in / Beteiligte Person: | Rollefstad, Silvia ; Tore K Kvien ; Anne Grete Semb ; Hilde Berner Hammer ; Terslev, L ; Lars Fridtjof Karoliussen ; Jensen, Gro |
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Zeitschrift: | RMD Open, Jg. 8 (2022-11-01), Heft 2 |
Veröffentlichung: | BMJ Publishing Group, 2022 |
Medientyp: | academicJournal |
ISSN: | 2056-5933 (print) |
DOI: | 10.1136/rmdopen-2022-002348 |
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