Radiation Therapy in the German Hodgkin Study Group HD 16 and HD 17 Trials: Quality Assurance and Dosimetric Analysis for Hodgkin Lymphoma in the Modern Era
In: Advances in Radiation Oncology, Jg. 8 (2023), Heft 3, S. 101169-
Online
academicJournal
Zugriff:
Purpose: Radiation therapy (RT) is an integral part of treatment concepts for early-stage Hodgkin lymphoma. This analysis reports on RT quality in the recent HD16 and 17 trials of the German Hodgkin Study Group (GHSG). Methods and Materials: All RT plans of involved-node radiation therapy (INRT) in HD 17 were requested for analysis, along with 100 and 50 involved-field radiation therapy (IFRT) plans in HD 16 and 17, respectively. A structured assessment regarding field design and protocol adherence was performed by the reference radiation oncology panel of the GHSG. Results: Overall, 100 (HD 16) and 176 (HD 17) patients were eligible for analysis. In HD 16, 84% of RT series were evaluated as correct, with significant improvement compared with the predecessor studies (P < .001). In HD 17, 76.1% of INRT cases revealed a correct RT design compared with 69.0% of IFRT-cases, which was superior to previous studies (P < .001). Comparing INRT and IFRT, we found no significant differences in the percentage of any deviation (P = .418) or major deviations (P = .466). Regarding dosimetry, INRT was accompanied by an improvement in thyroid doses. Comparing different RT techniques, we found that intensity-modulated RT showed a reduction of high doses in the lung at the expense of an increased low-dose exposure in HD 17. Conclusions: The latest study generation of the GHSG demonstrates an improved quality in RT. A modern INRT design could be established without deterioration in quality. On a conceptual level, an individual consideration of the appropriate RT technique has to be performed.
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Radiation Therapy in the German Hodgkin Study Group HD 16 and HD 17 Trials: Quality Assurance and Dosimetric Analysis for Hodgkin Lymphoma in the Modern Era
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Autor/in / Beteiligte Person: | Michael Oertel, MD ; Dominik Hering, MSc ; Nina Nacke, MSc ; Christopher Kittel, MSc ; Kai Kröger, MD ; Jan Kriz, MD ; Michael Fuchs, MD ; Christian Baues, MD ; Dirk Vordermark, MD ; Rita Engenhart-Cabillic, MD ; Klaus Herfarth, MD ; Peter Lukas, MD ; Heinz Schmidberger, MD ; Simone Marnitz, MD ; Peter Borchmann, MD ; Andreas Engert, MD ; Haverkamp, Uwe ; Hans Theodor Eich, MD |
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Zeitschrift: | Advances in Radiation Oncology, Jg. 8 (2023), Heft 3, S. 101169- |
Veröffentlichung: | Elsevier, 2023 |
Medientyp: | academicJournal |
ISSN: | 2452-1094 (print) |
DOI: | 10.1016/j.adro.2022.101169 |
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