CA19-9 in combination with P-CRP as a predictive marker of immune-related adverse events in patients with recurrent or unresectable advanced gastric cancer treated with nivolumab
In: BMC Cancer, Jg. 22 (2022), Heft 1, S. 1-10
Online
academicJournal
Zugriff:
Abstract Background Immune-check point inhibitors (ICPIs) for treatment of cancer patients sometimes induce potentially life-threatening immune-related adverse events (irAEs), which predict ICPIs treatment efficacy. Prediction of irAEs would be useful for management of irAEs and prediction of ICPIs efficacy. This study aimed to determine predictors of irAEs in patients with recurrent or unresectable advanced gastric cancer (RUGC) treated with nivolumab. Methods Seventy-eight RUGC patients treated with nivolumab at nine institutions between January 2017 and April 2020 were included in this study. The usefulness of specific blood test results as predictors of irAEs was evaluated. Results We observed irAEs in 15 (19.2%) patients. The disease control rate was significantly higher in the patients with irAEs than in those without (86.7% vs. 42.9%; P
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CA19-9 in combination with P-CRP as a predictive marker of immune-related adverse events in patients with recurrent or unresectable advanced gastric cancer treated with nivolumab
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| Autor/in / Beteiligte Person: | Matsunaga, Tomoyuki ; Saito, Hiroaki ; Kuroda, Hirohiko ; Osaki, Tomohiro ; Takahashi, Sadamu ; Iwamoto, Akemi ; Fukumoto, Yoji ; Taniguchi, Kenjiro ; Fukuda, Kenji ; Miyauchi, Wataru ; Shishido, Yuji ; Miyatani, Kozo ; Fujiwara, Yoshiyuki |
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| Zeitschrift: | BMC Cancer, Jg. 22 (2022), Heft 1, S. 1-10 |
| Veröffentlichung: | BMC, 2022 |
| Medientyp: | academicJournal |
| ISSN: | 1471-2407 (print) |
| DOI: | 10.1186/s12885-022-09482-8 |
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