Genetic deficiency of NOD2 confers resistance to invasive aspergillosis
In: Nature Communications, Jg. 9 (2018), Heft 1, S. 1-15
Online
academicJournal
Zugriff:
NOD2 has been shown to be crucial for immune recognition of Aspergillus infection. Here the authors show that a common NOD2 genetic variant associated with Crohn’s disease is associated with reduced risk of disease due to enhanced antifungal activates of monocytes and macrophages.
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Genetic deficiency of NOD2 confers resistance to invasive aspergillosis
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Autor/in / Beteiligte Person: | Gresnigt, Mark S. ; Cunha, Cristina ; Jaeger, Martin ; Gonçalves, Samuel M. ; R. K. Subbarao Malireddi ; Ammerdorffer, Anne ; Lubbers, Rosalie ; Oosting, Marije ; Rasid, Orhan ; Jouvion, Grégory ; Fitting, Catherine ; Dirk J. de Jong ; Lacerda, João F. ; Campos, António ; Melchers, Willem J. G. ; Lagrou, Katrien ; Maertens, Johan ; Kanneganti, Thirumala-Devi ; Carvalho, Agostinho ; Ibrahim-Granet, Oumaima ; Frank L. van de Veerdonk |
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Zeitschrift: | Nature Communications, Jg. 9 (2018), Heft 1, S. 1-15 |
Veröffentlichung: | Nature Portfolio, 2018 |
Medientyp: | academicJournal |
ISSN: | 2041-1723 (print) |
DOI: | 10.1038/s41467-018-04912-3 |
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