Enhanced influenza A H1N1 T cell epitope recognition and cross-reactivity to protein-O-mannosyltransferase 1 in Pandemrix-associated narcolepsy type 1
In: Nature Communications, Jg. 12 (2021), Heft 1, S. 1-17
Online
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Zugriff:
Narcolepsy type 1 (NT1) is a severe sleep disorder with strong association to the HLA type DQB1*0602 and increased incidence among children vaccinated with the Influenza A vaccine Pandemrix. Here the authors show that these children develop T and B cell autoimmunity against protein-O-mannosyltransferase 1 via cross-reactivity.
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Enhanced influenza A H1N1 T cell epitope recognition and cross-reactivity to protein-O-mannosyltransferase 1 in Pandemrix-associated narcolepsy type 1
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Autor/in / Beteiligte Person: | Vuorela, A. ; Freitag, T. L. ; Leskinen, K. ; Pessa, H. ; Härkönen, T. ; Stracenski, I. ; Kirjavainen, T. ; Olsen, P. ; Saarenpää-Heikkilä, O. ; Ilonen, J. ; Knip, M. ; Vaheri, A. ; Partinen, M. ; Saavalainen, P. ; Meri, S. ; Vaarala, O. |
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Zeitschrift: | Nature Communications, Jg. 12 (2021), Heft 1, S. 1-17 |
Veröffentlichung: | Nature Portfolio, 2021 |
Medientyp: | academicJournal |
ISSN: | 2041-1723 (print) |
DOI: | 10.1038/s41467-021-22637-8 |
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