Lactate: a multifunctional signaling molecule
In: Yeungnam University Journal of Medicine, Jg. 38 (2021), Heft 3, S. 183-193
Online
academicJournal
Zugriff:
Since its discovery in 1780, lactate has long been misunderstood as a waste by-product of anaerobic glycolysis with multiple deleterious effects. Owing to the lactate shuttle concept introduced in the early 1980s, a paradigm shift began to occur. Increasing evidence indicates that lactate is a coordinator of whole-body metabolism. Lactate is not only a readily accessible fuel that is shuttled throughout the body but also a metabolic buffer that bridges glycolysis and oxidative phosphorylation between cells and intracellular compartments. Lactate also acts as a multifunctional signaling molecule through receptors expressed in various cells and tissues, resulting in diverse biological consequences including decreased lipolysis, immune regulation, anti-inflammation, wound healing, and enhanced exercise performance in association with the gut microbiome. Furthermore, lactate contributes to epigenetic gene regulation by lactylating lysine residues of histones, accounting for its key role in immune modulation and maintenance of homeostasis.
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Lactate: a multifunctional signaling molecule
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Autor/in / Beteiligte Person: | Lee, Tae-Yoon |
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Zeitschrift: | Yeungnam University Journal of Medicine, Jg. 38 (2021), Heft 3, S. 183-193 |
Veröffentlichung: | Yeungnam University College of Medicine, 2021 |
Medientyp: | academicJournal |
ISSN: | 2384-0293 (print) |
DOI: | 10.12701/yujm.2020.00892 |
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