Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1
In: Nature Communications, Jg. 9 (2018), Heft 1, S. 1-21
Online
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Zugriff:
Additional sex combs-like (ASXLs) stimulate BAP1 deubiquitinase activity to induce tumor suppression, but how these complexes work in coordination in vivo is unclear. Here, the authors show the mutually reinforcing roles of BAP1 and ASXLs such that BAP1 promotes DEUBAD monoubiquitination of ASXL2, which in turn stimulates BAP1 DUB activity.
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Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1
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Autor/in / Beteiligte Person: | Daou, Salima ; Barbour, Haithem ; Ahmed, Oumaima ; Masclef, Louis ; Baril, Caroline ; Nadine Sen Nkwe ; Tchelougou, Daméhan ; Uriarte, Maxime ; Bonneil, Eric ; Ceccarelli, Derek ; Mashtalir, Nazar ; Tanji, Mika ; Masson, Jean-Yves ; Thibault, Pierre ; Sicheri, Frank ; Yang, Haining ; Carbone, Michele ; Therrien, Marc ; El Bachir Affar |
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Zeitschrift: | Nature Communications, Jg. 9 (2018), Heft 1, S. 1-21 |
Veröffentlichung: | Nature Portfolio, 2018 |
Medientyp: | academicJournal |
ISSN: | 2041-1723 (print) |
DOI: | 10.1038/s41467-018-06854-2 |
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