Predictive Factors of Response to Immunotherapy in Lymphomas: A Multicentre Clinical Data Warehouse Study (PRONOSTIM)
In: Cancers, Jg. 15 (2023-08-01), Heft 16, S. 4028
Online
academicJournal
Zugriff:
Immunotherapy (IT) is a major therapeutic strategy for lymphoma, significantly improving patient prognosis. IT remains ineffective for a significant number of patients, however, and exposes them to specific toxicities. The identification predictive factors around efficacy and toxicity would allow better targeting of patients with a higher ratio of benefit to risk. PRONOSTIM is a multicenter and retrospective study using the Clinical Data Warehouse (CDW) of the Greater Paris University Hospitals network. Adult patients with Hodgkin lymphoma or diffuse large-cell B lymphoma treated with immune checkpoint inhibitors or CAR T (Chimeric antigen receptor T) cells between 2017 and 2022 were included. Analysis of covariates influencing progression-free survival (PFS) or the occurrence of grade ≥3 toxicity was performed. In total, 249 patients were included. From this study, already known predictors for response or toxicity of CAR T cells such as age, elevated lactate dehydrogenase, and elevated C-Reactive Protein at the time of infusion were confirmed. In addition, male gender, low hemoglobin, and hypo- or hyperkalemia were demonstrated to be potential predictive factors for progression after CAR T cell therapy. These findings prove the attractiveness of CDW in generating real-world data, and show its essential contribution to identifying new predictors for decision support before starting IT.
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Predictive Factors of Response to Immunotherapy in Lymphomas: A Multicentre Clinical Data Warehouse Study (PRONOSTIM)
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Autor/in / Beteiligte Person: | Detroit, Marion ; Collier, Mathis ; Beeker, Nathanaël ; Willems, Lise ; Decroocq, Justine ; Deau-Fischer, Bénédicte ; Vignon, Marguerite ; Birsen, Rudy ; Moufle, Frederique ; Leclaire, Clément ; Balladur, Elisabeth ; Deschamps, Paul ; Chauchet, Adrien ; Batista, Rui ; Limat, Samuel ; Treluyer, Jean-Marc ; Ricard, Laure ; Stocker, Nicolas ; Hermine, Olivier ; Choquet, Sylvain ; Morel, Véronique ; Metz, Carole ; Bouscary, Didier ; Kroemer, Marie ; Zerbit, Jérémie |
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Zeitschrift: | Cancers, Jg. 15 (2023-08-01), Heft 16, S. 4028 |
Veröffentlichung: | MDPI AG, 2023 |
Medientyp: | academicJournal |
ISSN: | 2072-6694 (print) |
DOI: | 10.3390/cancers15164028 |
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