Functional characterization of T2D-associated SNP effects on baseline and ER stress-responsive β cell transcriptional activation
In: Nature Communications, Jg. 12 (2021), Heft 1, S. 1-13
Online
academicJournal
Zugriff:
Identifying causal variants at GWAS loci is important to understand disease mechanisms. Here the authors use massively parallel reporter assays to identify type 2 diabetes-associated variants that alter cis-regulatory activity, narrowing in on the causal variants and genetic mechanisms behind the disease.
Titel: |
Functional characterization of T2D-associated SNP effects on baseline and ER stress-responsive β cell transcriptional activation
|
---|---|
Autor/in / Beteiligte Person: | Khetan, Shubham ; Kales, Susan ; Kursawe, Romy ; Jillette, Alexandria ; Ulirsch, Jacob C. ; Reilly, Steven K. ; Ucar, Duygu ; Tewhey, Ryan ; Stitzel, Michael L. |
Link: | |
Zeitschrift: | Nature Communications, Jg. 12 (2021), Heft 1, S. 1-13 |
Veröffentlichung: | Nature Portfolio, 2021 |
Medientyp: | academicJournal |
ISSN: | 2041-1723 (print) |
DOI: | 10.1038/s41467-021-25514-6 |
Schlagwort: |
|
Sonstiges: |
|