A fungal sesquiterpene biosynthesis gene cluster critical for mutualist-pathogen transition in Colletotrichum tofieldiae
In: Nature Communications, Jg. 14 (2023), Heft 1, S. 1-18
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Zugriff:
Abstract Plant-associated fungi show diverse lifestyles from pathogenic to mutualistic to the host; however, the principles and mechanisms through which they shift the lifestyles require elucidation. The root fungus Colletotrichum tofieldiae (Ct) promotes Arabidopsis thaliana growth under phosphate limiting conditions. Here we describe a Ct strain, designated Ct3, that severely inhibits plant growth. Ct3 pathogenesis occurs through activation of host abscisic acid pathways via a fungal secondary metabolism gene cluster related to the biosynthesis of sesquiterpene metabolites, including botrydial. Cluster activation during root infection suppresses host nutrient uptake-related genes and changes mineral contents, suggesting a role in manipulating host nutrition state. Conversely, disruption or environmental suppression of the cluster renders Ct3 beneficial for plant growth, in a manner dependent on host phosphate starvation response regulators. Our findings indicate that a fungal metabolism cluster provides a means by which infectious fungi modulate lifestyles along the parasitic–mutualistic continuum in fluctuating environments.
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A fungal sesquiterpene biosynthesis gene cluster critical for mutualist-pathogen transition in Colletotrichum tofieldiae
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Autor/in / Beteiligte Person: | Hiruma, Kei ; Aoki, Seishiro ; Takino, Junya ; Higa, Takeshi ; Yuniar Devi Utami ; Shiina, Akito ; Okamoto, Masanori ; Nakamura, Masami ; Kawamura, Nanami ; Ohmori, Yoshihiro ; Sugita, Ryohei ; Tanoi, Keitaro ; Sato, Toyozo ; Oikawa, Hideaki ; Minami, Atsushi ; Iwasaki, Wataru ; Saijo, Yusuke |
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Zeitschrift: | Nature Communications, Jg. 14 (2023), Heft 1, S. 1-18 |
Veröffentlichung: | Nature Portfolio, 2023 |
Medientyp: | academicJournal |
ISSN: | 2041-1723 (print) |
DOI: | 10.1038/s41467-023-40867-w |
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