Agrin-Matrix Metalloproteinase-12 axis confers a mechanically competent microenvironment in skin wound healing
In: Nature Communications, Jg. 12 (2021), Heft 1, S. 1-18
Online
academicJournal
Zugriff:
Replenishing key extracellular matrix (ECM) proteins facilitate wound healing through unclear mechanisms. Here the authors report that injury-triggered Agrin, an ECM proteoglycan, tunes a mechanocompetent niche by engaging MMP-12, thereby enforcing efficient skin wound healing.
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Agrin-Matrix Metalloproteinase-12 axis confers a mechanically competent microenvironment in skin wound healing
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Autor/in / Beteiligte Person: | Chakraborty, Sayan ; Sampath, Divyaleka ; Melissa Ong Yu Lin ; Bilton, Matthew ; Huang, Cheng-Kuang ; Mui Hoon Nai ; Njah, Kizito ; Goy, Pierre-Alexis ; Wang, Cheng-Chun ; Guccione, Ernesto ; Lim, Chwee-Teck ; Hong, Wanjin |
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Zeitschrift: | Nature Communications, Jg. 12 (2021), Heft 1, S. 1-18 |
Veröffentlichung: | Nature Portfolio, 2021 |
Medientyp: | academicJournal |
ISSN: | 2041-1723 (print) |
DOI: | 10.1038/s41467-021-26717-7 |
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