SARS-CoV-2 seroprevalence in pregnant women in Kilifi, Kenya from March 2020 to March 2022
In: Frontiers in Public Health, Jg. 11 (2023-12-01)
Online
academicJournal
Zugriff:
BackgroundSeroprevalence studies are an alternative approach to estimating the extent of transmission of SARS-CoV-2 and the evolution of the pandemic in different geographical settings. We aimed to determine the SARS-CoV-2 seroprevalence from March 2020 to March 2022 in a rural and urban setting in Kilifi County, Kenya.MethodsWe obtained representative random samples of stored serum from a pregnancy cohort study for the period March 2020 to March 2022 and tested for antibodies against the spike protein using a qualitative SARS-CoV-2 ELISA kit (Wantai, total antibodies). All positive samples were retested for anti-SARS-CoV-2 anti-nucleocapsid antibodies (Euroimmun, ELISA kits, NCP, qualitative, IgG) and anti-spike protein antibodies (Euroimmun, ELISA kits, QuantiVac; quantitative, IgG).ResultsA total of 2,495 (of 4,703 available) samples were tested. There was an overall trend of increasing seropositivity from a low of 0% [95% CI 0–0.06] in March 2020 to a high of 89.4% [95% CI 83.36–93.82] in Feb 2022. Of the Wantai test-positive samples, 59.7% [95% CI 57.06–62.34] tested positive by the Euroimmun anti-SARS-CoV-2 NCP test and 37.4% [95% CI 34.83–40.04] tested positive by the Euroimmun anti-SARS-CoV-2 QuantiVac test. No differences were observed between the urban and rural hospital but villages adjacent to the major highway traversing the study area had a higher seroprevalence.ConclusionAnti-SARS-CoV-2 seroprevalence rose rapidly, with most of the population exposed to SARS-CoV-2 within 23 months of the first cases. The high cumulative seroprevalence suggests greater population exposure to SARS-CoV-2 than that reported from surveillance data.
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SARS-CoV-2 seroprevalence in pregnant women in Kilifi, Kenya from March 2020 to March 2022
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Autor/in / Beteiligte Person: | Koech, Angela ; Omuse, Geoffrey ; Mugo, Alex G. ; Mwaniki, Isaac G. ; Mutunga, Joseph M. ; Mukhanya, Moses W. ; Wanje, Onesmus ; Mwashigadi, Grace M. ; Katana, Geoffrey G. ; Craik, Rachel ; Peter von Dadelszen ; Kirsty Le Doare ; Temmerman, Marleen ; periCOVID-Africa ; The PRECISE Network ; Freyne, Bridget ; Kawaza, Kondwani ; Lissauer, Samantha ; Sommerfelt, Halvor ; Etti, Melanie ; Musoke, Philippa ; Mboizi, Robert ; Cose, Stephen ; Nankabirwa, Victoria ; Hookham, Lauren ; Ouma, Joseph ; Rukondo, Gordon ; Cochet, Madeleine ; Voysey, Merryn ; Cantrell, Liberty ; Okiro, Patricia ; Juma, Consolata ; Ochieng, Marvin ; Mwadime, Emily ; Sevene, Esperança ; Tchavana, Corssino ; Macuacua, Salesio ; Vala, Anifa ; Boene, Helena ; Quimice, Lazaro ; Maculuve, Sonia ; Macete, Eusebio ; Mandomando, Inacio ; Carillho, Carla ; D’Alessandro, Umberto ; Roca, Anna ; Jah, Hawanatu ; Prentice, Andrew ; Martinez-Alvarez, Melisa ; Diallo, Brahima ; Sesay, Abdul ; Suso, Sambou ; Njie, Baboucarr ; Touray, Fatima ; Idris, Yahaya ; Kongira, Fatoumata ; Modou F.S. Ndure ; Gabbidon, Gibril ; Gibba, Lawrence ; Bah, Abdoulie ; Bah, Yorro ; Magee, Laura A. ; Mistry, Hiten ; Volvert, Marie-Laure ; Mendy, Thomas ; Poston, Lucilla ; Sandall, Jane ; Tribe, Rachel ; Moore, Sophie ; Salisbury, Tatiana T. ; Russell, Donna ; Makanga, Prestige T. ; Makacha, Liberty ; Mlambo, Reason ; Papageorghiou, Aris ; Noble, Alison ; Blencowe, Hannah ; Filippi, Veronique ; Lawn, Joy ; Silver, Matt ; Waiswa, Joseph ; Gazeley, Ursula ; Cartwright, Judith ; Whitley, Guy ; Krishna, Sanjeev ; Vidler, Marianne ; Jing (Larry) Li ; Bone, Jeff ; Mai-Lei (Maggie) W Kinshella ; Tu, Domena ; Sandhu, Ash ; Pickerill, Kelly ; Barratt, Ben |
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Zeitschrift: | Frontiers in Public Health, Jg. 11 (2023-12-01) |
Veröffentlichung: | Frontiers Media S.A., 2023 |
Medientyp: | academicJournal |
ISSN: | 2296-2565 (print) |
DOI: | 10.3389/fpubh.2023.1292932 |
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