Molecular basis of reduced LAIR1 expression in childhood severe malarial anaemia: Implications for leukocyte inhibitory signallingResearch in context
In: EBioMedicine, Jg. 45 (2019-07-01), Heft 278-289, S. 278-289
Online
academicJournal
Zugriff:
Background: Leukocyte-associated immunoglobulin like receptor-1 (LAIR1) is a transmembrane inhibitory receptor that influences susceptibility to a myriad of inflammatory diseases. Our recent investigations of severe malarial anaemia (SMA) pathogenesis in Kenyan children discovered that novel LAIR1 genetic variants which were associated with decreased LAIR1 transcripts enhanced the longitudinal risk of SMA and all-cause mortality. Methods: To characterize the molecular mechanism(s) responsible for altered LAIR1 signalling in severe malaria, we determined LAIR1 transcripts and protein, sLAIR1, sLAIR2, and complement component 1q (C1q) in children with malarial anaemia, followed by a series of in vitro experiments investigating the LAIR1 signalling cascade. Findings: Kenyan children with SMA had elevated circulating levels of soluble LAIR1 (sLAIR1) relative to non-SMA (1.69-fold P
Titel: |
Molecular basis of reduced LAIR1 expression in childhood severe malarial anaemia: Implications for leukocyte inhibitory signallingResearch in context
|
---|---|
Autor/in / Beteiligte Person: | Achieng, Angela O. ; Guyah, Bernard ; Cheng, Qiuying ; Ong'echa, John M. ; Ouma, Collins ; Lambert, Christophe G. ; Perkins, Douglas J. |
Link: | |
Zeitschrift: | EBioMedicine, Jg. 45 (2019-07-01), Heft 278-289, S. 278-289 |
Veröffentlichung: | Elsevier, 2019 |
Medientyp: | academicJournal |
ISSN: | 2352-3964 (print) |
DOI: | 10.1016/j.ebiom.2019.06.040 |
Schlagwort: |
|
Sonstiges: |
|