The Effect of α-Arbutin on UVB-Induced Damage and Its Underlying Mechanism
In: Molecules, Jg. 29 (2024-04-01), Heft 9, S. 1921
Online
academicJournal
Zugriff:
Ultraviolet radiation can heighten tyrosinase activity, stimulate melanocyte production, impede the metabolism of numerous melanocytes, and result in the accumulation of plaques on the skin surface. α-Arbutin, a bioactive substance extracted from the arbutin plant, has been widely used for skin whitening. In this study, the whitening effect of α-arbutin by inhibiting tyrosinase activity and alleviating the photoaging effect induced by UVB are investigated. The results indicate that α-arbutin can inhibit skin inflammation, and its effectiveness is positively correlated with concentration. Moreover, α-arbutin can reduce the skin epidermal thickness, decrease the number of inflammatory cells, and down-regulate the expression levels of IL-1β, IL-6 and TNF-α, which are inflammatory factors. It also promotes the expression of COL-1 collagen, thus playing an important role in anti-inflammatory action. Network pharmacology, metabolomics and transcriptomics further confirm that α-arbutin is related to the L-tyrosine metabolic pathway and may interfere with various signaling pathways related to melanin and other photoaging by regulating metabolic changes. Therefore, α-arbutin has a potential inhibitory effect on UVB-induced photoaging and possesses a whitening effect as a cosmetic compound.
Titel: |
The Effect of α-Arbutin on UVB-Induced Damage and Its Underlying Mechanism
|
---|---|
Autor/in / Beteiligte Person: | Shu, Peng ; Wang, Yuan ; Zhang, Lanyue |
Link: | |
Zeitschrift: | Molecules, Jg. 29 (2024-04-01), Heft 9, S. 1921 |
Veröffentlichung: | MDPI AG, 2024 |
Medientyp: | academicJournal |
ISSN: | 1420-3049 (print) |
DOI: | 10.3390/molecules29091921 |
Schlagwort: |
|
Sonstiges: |
|