MCOLN1 is a ROS sensor in lysosomes that regulates autophagy
In: Nature Communications, Jg. 7 (2016), Heft 1, S. 1-12
Online
academicJournal
Zugriff:
Reactive oxygen species (ROS) damage cell components, necessitating their clearance through autophagy. Here, the authors show that ROS can induce autophagy by triggering TRPML1 to release Ca2+from the lysosomal lumen, in turn activating the autophagy and lysosomal biogenesis regulator TFEB.
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MCOLN1 is a ROS sensor in lysosomes that regulates autophagy
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Autor/in / Beteiligte Person: | Zhang, Xiaoli ; Cheng, Xiping ; Yu, Lu ; Yang, Junsheng ; Calvo, Raul ; Patnaik, Samarjit ; Hu, Xin ; Gao, Qiong ; Yang, Meimei ; Lawas, Maria ; Delling, Markus ; Marugan, Juan ; Ferrer, Marc ; Xu, Haoxing |
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Zeitschrift: | Nature Communications, Jg. 7 (2016), Heft 1, S. 1-12 |
Veröffentlichung: | Nature Portfolio, 2016 |
Medientyp: | academicJournal |
ISSN: | 2041-1723 (print) |
DOI: | 10.1038/ncomms12109 |
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