Treatment outcome and survival status among adult patients treated for lupus nephritis in selected tertiary hospitals of Ethiopia
In: Scientific Reports, Jg. 14 (2024), Heft 1, S. 1-13
Online
academicJournal
Zugriff:
Abstract Lupus nephritis (LN) is kidney involvement of systematic lupus erythematous that ranges from mild to severe and occurs in 60% of adult patients. Despite advances in therapy, LN morbidity and mortality remains high. There is a paucity of data regarding adult LN patient's treatment outcome, survival status, and associated factors in developing countries, particularly in Ethiopia. This study aimed to assess the treatment outcome, survival status, and associated factors of adult patients treated for LN in two selected tertiary hospitals [Tikur Anbessa Specialized Hospital (TASH) and St. Paul’s Hospital Millennium Medical College (SPHMMC)] of Addis Ababa, Ethiopia. A hospital-based retrospective cross-sectional multicenter study was conducted from January 1, 2016 to January 1, 2021. Socio-demographic, clinical, and treatment-related data were collected from patient’s medical records by using a structured abstraction checklist. Descriptive statistics were used to summarize the quantitative data as appropriate. The modified Aspreva Lupus Management Study (mALMS) criteria was applied to categorize LN treatment outcomes into complete, partial, and non-response. Multinomial logistic regression analysis was performed to identify predictors of LN treatment outcome. Patients’ survival was estimated by using Kaplan–Meier and Cox proportion regression analysis. P value
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Treatment outcome and survival status among adult patients treated for lupus nephritis in selected tertiary hospitals of Ethiopia
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Autor/in / Beteiligte Person: | Aliyi, Oumer ; Worku, Berhanu ; Hassen, Minimize ; Oumer Sada Muhammed |
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Zeitschrift: | Scientific Reports, Jg. 14 (2024), Heft 1, S. 1-13 |
Veröffentlichung: | Nature Portfolio, 2024 |
Medientyp: | academicJournal |
ISSN: | 2045-2322 (print) |
DOI: | 10.1038/s41598-024-56317-6 |
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