Prevalence of estrogen receptor alpha PvuII (c454-397T>C) and XbaI (c454A>G) polymorphisms in a population of Brazilian women
In: Brazilian Archives of Biology and Technology, Jg. 54 (2011), Heft 6, S. 1151-1158
Online
academicJournal
Zugriff:
The aim of this work was to study the estrogen receptor alpha (ERS1) PvuII and XbaI gene polymorphisms prevalence in randomly selected women population from Rio de Janeiro and Espírito Santo states in Brazil by polymerase chain reaction restriction fragment lengths polymorphism (PCR_RFLP) methodology. It was shown that Rio de Janeiro women exhibited a significantly different prevalence of XbaI polymorphism comparing to Espirito Santo women. Nonetheless, similar prevalence of PvuII polymorphism was found in both women´s populations. Moreover, a strong linkage disequilibrium was observed between these SNPs reinforcing the hypothesis of differential pattern of inheritance observed on such populations.
| Titel: |
Prevalence of estrogen receptor alpha PvuII (c454-397T>C) and XbaI (c454A>G) polymorphisms in a population of Brazilian women
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| Autor/in / Beteiligte Person: | Karine Lourenzone Araújo ; Lucas Cunha Dias de Rezende ; Letícia Soncini Souza ; Renata Dalmaschio Daltoé ; Klesia Pirola Madeira ; Marcela Ferreira Paes ; Fernando Luiz Herkenhoff ; Letícia Batista Azevedo Rangel ; Ian Victor Silva |
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| Zeitschrift: | Brazilian Archives of Biology and Technology, Jg. 54 (2011), Heft 6, S. 1151-1158 |
| Veröffentlichung: | Instituto de Tecnologia do Paraná (Tecpar), 2011 |
| Medientyp: | academicJournal |
| ISSN: | 1516-8913 (print) ; 1678-4324 (print) |
| DOI: | 10.1590/S1516-89132011000600010 |
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