Treatment and diagnosis of severe KPC-producing Klebsiella pneumoniae infections: a perspective on what has changed over last decades
In: Annals of Medicine, Jg. 55 (2023), Heft 1, S. 101-113
Online
academicJournal
Zugriff:
AbstractAntimicrobial resistance is a global health threat. Among Gram-negative bacteria, resistance to carbapenems, a class of β-lactam antibiotics, is usually a proxy for difficult-to-treat resistance, since carbapenem-resistant organisms are often resistant to many classes of antibiotics. Carbapenem resistance in the Gram-negative pathogen Klebsiella pneumoniae is mostly due to the production of carbapenemases, enzymes able to hydrolyze carbapenems, and K. pneumoniae carbapenemase (KPC)-type enzymes are overall the most prevalent carbapenemases in K. pneumoniae. In the last decade, the management of severe infections due to KPC-producing K. pneumoniae (KPC-Kp) in humans has presented many peculiar challenges to clinicians worldwide. In this perspective, we discuss how the treatment of severe KPC-Kp infections has evolved over the last decades, guided by the accumulating evidence from clinical studies, and how recent advances in diagnostics have allowed to anticipate identification of KPC-Kp in infected patients.KEY MESSAGESIn the last decade, the management of severe infections due to KPC-Kp has presented many peculiar challenges to clinicians worldwideFollowing the introduction in clinical practice of novel β-lactam/β-lactamase inhibitor combinations and novel β-lactams active against KPC-producing bacteria, the management of severe KPC-Kp infections has witnessed a remarkable evolutionTreatment of severe KPC-Kp infections is a highly dynamic process, in which the wise use of novel antimicrobials should be accompanied by a continuous refinement based on evolving clinical evidence and laboratory diagnostics
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Treatment and diagnosis of severe KPC-producing Klebsiella pneumoniae infections: a perspective on what has changed over last decades
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Autor/in / Beteiligte Person: | Daniele Roberto Giacobbe ; Vincenzo Di Pilato ; Karaiskos, Ilias ; Giani, Tommaso ; Marchese, Anna ; Gian Maria Rossolini ; Bassetti, Matteo |
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Zeitschrift: | Annals of Medicine, Jg. 55 (2023), Heft 1, S. 101-113 |
Veröffentlichung: | Taylor & Francis Group, 2023 |
Medientyp: | academicJournal |
ISSN: | 0785-3890 (print) ; 1365-2060 (print) |
DOI: | 10.1080/07853890.2022.2152484 |
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