Haplotype of non-synonymous mutations within IL-23R is associated with susceptibility to severe malaria anemia in a P. falciparum holoendemic transmission area of Kenya
In: BMC Infectious Diseases, Jg. 17 (2017), Heft 1, S. 1-9
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Abstract Background Improved understanding of the molecular mechanisms involved in pediatric severe malarial anemia (SMA) pathogenesis is a crucial step in the design of novel therapeutics. Identification of host genetic susceptibility factors in immune regulatory genes offers an important tool for deciphering malaria pathogenesis. The IL-23/IL-17 immune pathway is important for both immunity and erythropoiesis via its effects through IL-23 receptors (IL-23R). However, the impact of IL-23R variants on SMA has not been fully elucidated. Methods Since variation within the coding region of IL-23R may influence the pathogenesis of SMA, the association between IL-23R rs1884444 (G/T), rs7530511 (C/T), and SMA (Hb
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Haplotype of non-synonymous mutations within IL-23R is associated with susceptibility to severe malaria anemia in a P. falciparum holoendemic transmission area of Kenya
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Autor/in / Beteiligte Person: | Munde, Elly O. ; Raballah, Evans ; Okeyo, Winnie A. ; Ong’echa, John M. ; Perkins, Douglas J. ; Ouma, Collins |
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Zeitschrift: | BMC Infectious Diseases, Jg. 17 (2017), Heft 1, S. 1-9 |
Veröffentlichung: | BMC, 2017 |
Medientyp: | academicJournal |
ISSN: | 1471-2334 (print) |
DOI: | 10.1186/s12879-017-2404-y |
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