Plasma angiopoietin-2 is associated with age-related deficits in cognitive sub-scales in Ugandan children following severe malaria
In: Malaria Journal, Jg. 20 (2021), Heft 1, S. 1-10
Online
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Zugriff:
Abstract Background Elevated angiopoietin-2 (Angpt-2) concentrations are associated with worse overall neurocognitive function in severe malaria survivors, but the specific domains affected have not been elucidated. Methods Ugandan children with severe malaria underwent neurocognitive evaluation a week after hospital discharge and at 6, 12 and 24 months follow-up. The relationship between Angpt-2 concentrations and age-adjusted, cognitive sub-scale z-scores over time were evaluated using linear mixed effects models, adjusting for disease severity (coma, acute kidney injury, number of seizures in hospital) and sociodemographic factors (age, gender, height-for-age z-score, socio-economic status, enrichment in the home environment, parental education, and any preschool education of the child). The Mullen Scales of Early Learning was used in children
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Plasma angiopoietin-2 is associated with age-related deficits in cognitive sub-scales in Ugandan children following severe malaria
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Autor/in / Beteiligte Person: | Ouma, Benson J. ; Bangirana, Paul ; Ssenkusu, John M. ; Datta, Dibyadyuti ; Opoka, Robert O. ; Idro, Richard ; Kain, Kevin C. ; John, Chandy C. ; Conroy, Andrea L. |
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Zeitschrift: | Malaria Journal, Jg. 20 (2021), Heft 1, S. 1-10 |
Veröffentlichung: | BMC, 2021 |
Medientyp: | academicJournal |
ISSN: | 1475-2875 (print) |
DOI: | 10.1186/s12936-020-03545-6 |
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