Kidney Transplantation, Immunosuppression and the Risk of Fracture: Clinical and Economic ImplicationsPlain-Language Summary
In: Kidney Medicine, Jg. 4 (2022), Heft 6, S. 100474-
Online
academicJournal
Zugriff:
Rationale & Objective: Disorders of bone and mineral metabolism frequently develop with advanced kidney disease, may be exacerbated by immunosuppression after kidney transplantation, and increase the risk of fractures. Study Design: Retrospective database study. Setting & Participants: Kidney-only transplant recipients aged ≥18 years from 2005 to 2016 in the United States captured in US Renal Data System records, which integrate Organ Procurement and Transplantation Network/United Network for Organ Sharing records with Medicare billing claims. Exposures: Various immunosuppression regimens in the first 3 months after kidney transplantation. Outcomes: The development of fractures, as ascertained using diagnostic codes on Medicare billing claims. Analytical Approach: We used multivariable Cox regression with inverse propensity weighting to compare the incidence of fractures >3 months-to-3 years after kidney transplantation associated with various immunosuppression regimens compared to a reference regimen of antithymocyte globulin (TMG) or alemtuzumab (ALEM) with tacrolimus + mycophenolic acid + prednisone using inverse probability treatment weighting. Results: Overall, fractures were identified in 7.5% of kidney transplant recipients (women, 8.8%; men, 6.7%; age
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Kidney Transplantation, Immunosuppression and the Risk of Fracture: Clinical and Economic ImplicationsPlain-Language Summary
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Autor/in / Beteiligte Person: | Sarat Kuppachi, MBBS ; Cheungpasitporn, Wisit ; Li, Ruixin ; Caliskan, Yasar ; Schnitzler, Mark A. ; McAdams-DeMarco, Mara ; Ahn, JiYoon B. ; Bae, Sunjae ; Hess, Gregory P. ; Segev, Dorry L. ; Lentine, Krista L. ; Axelrod, David A. |
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Zeitschrift: | Kidney Medicine, Jg. 4 (2022), Heft 6, S. 100474- |
Veröffentlichung: | Elsevier, 2022 |
Medientyp: | academicJournal |
ISSN: | 2590-0595 (print) |
DOI: | 10.1016/j.xkme.2022.100474 |
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