VAR2CSA Serology to Detect Plasmodium falciparum Transmission Patterns in Pregnancy
In: Emerging Infectious Diseases, Jg. 25 (2019), Heft 10, S. 1851-1860
Online
academicJournal
Zugriff:
Pregnant women constitute a promising sentinel group for continuous monitoring of malaria transmission. To identify antibody signatures of recent Plasmodium falciparum exposure during pregnancy, we dissected IgG responses against VAR2CSA, the parasite antigen that mediates placental sequestration. We used a multiplex peptide-based suspension array in 2,354 samples from pregnant women from Mozambique, Benin, Kenya, Gabon, Tanzania, and Spain. Two VAR2CSA peptides of limited polymorphism were immunogenic and targeted by IgG responses readily boosted during infection and with estimated half-lives of
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VAR2CSA Serology to Detect Plasmodium falciparum Transmission Patterns in Pregnancy
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Autor/in / Beteiligte Person: | Ana Maria Fonseca ; González, Raquel ; Bardají, Azucena ; Jairoce, Chenjerai ; Rupérez, Maria ; Jiménez, Alfons ; Quintó, Llorenç ; Cisteró, Pau ; Vala, Anifa ; Sacoor, Charfudin ; Gupta, Himanshu ; Hegewisch-Taylor, Jennifer ; Brew, Joe ; Nicaise Tuikue Ndam ; Kariuki, Simon ; López, Marta ; Dobaño, Carlota ; Chitnis, Chetan E. ; Ouma, Peter ; Ramharter, Michael ; Abdulla, Salim ; Aponte, John J. ; Massougbodji, Achille ; Briand, Valerie ; Mombo-Ngoma, Ghyslain ; Desai, Meghna ; Cot, Michel ; Nhacolo, Arsenio ; Sevene, Esperança ; Macete, Eusebio ; Menéndez, Clara ; Mayor, Alfredo |
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Zeitschrift: | Emerging Infectious Diseases, Jg. 25 (2019), Heft 10, S. 1851-1860 |
Veröffentlichung: | Centers for Disease Control and Prevention, 2019 |
Medientyp: | academicJournal |
ISSN: | 1080-6040 (print) ; 1080-6059 (print) |
DOI: | 10.3201/eid2510.181177 |
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