High seroprevalence of SARS-CoV-2 but low infection fatality ratio eight months after introduction in Nairobi, Kenya
In: International Journal of Infectious Diseases, Jg. 112 (2021-11-01), Heft 25-34, S. 25-34
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Zugriff:
ABSTRACT: Background: The lower than expected COVID-19 morbidity and mortality in Africa has been attributed to multiple factors, including weak surveillance. This study estimated the burden of SARS-CoV-2 infections eight months into the epidemic in Nairobi, Kenya. Methods: A population-based, cross-sectional survey was conducted using multi-stage random sampling to select households within Nairobi in November 2020. Sera from consenting household members were tested for antibodies to SARS-CoV-2. Seroprevalence was estimated after adjusting for population structure and test performance. Infection fatality ratios (IFRs) were calculated by comparing study estimates with reported cases and deaths. Results: Among 1,164 individuals, the adjusted seroprevalence was 34.7% (95% CI 31.8-37.6). Half of the enrolled households had at least one positive participant. Seropositivity increased in more densely populated areas (spearman's r=0.63; p=0.009). Individuals aged 20-59 years had at least two-fold higher seropositivity than those aged 0-9 years. The IFR was 40 per 100,000 infections, with individuals ≥60 years old having higher IFRs. Conclusion: Over one-third of Nairobi residents had been exposed to SARS-CoV-2 by November 2020, indicating extensive transmission. However, the IFR was >10-fold lower than that reported in Europe and the USA, supporting the perceived lower morbidity and mortality in sub-Saharan Africa.
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High seroprevalence of SARS-CoV-2 but low infection fatality ratio eight months after introduction in Nairobi, Kenya
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Autor/in / Beteiligte Person: | Ngere, Isaac ; Dawa, Jeanette ; Hunsperger, Elizabeth ; Otieno, Nancy ; Masika, Moses ; Amoth, Patrick ; Makayotto, Lyndah ; Nasimiyu, Carolyne ; Gunn, Bronwyn M. ; Nyawanda, Bryan ; Oluga, Ouma ; Ngunu, Carolyne ; Mirieri, Harriet ; Gachohi, John ; Marwanga, Doris ; Munywoki, Patrick K. ; Odhiambo, Dennis ; Alando, Moshe D. ; Breiman, Robert F. ; Anzala, Omu ; M. Kariuki Njenga ; Bulterys, Marc ; Herman-Roloff, Amy ; Osoro, Eric |
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Zeitschrift: | International Journal of Infectious Diseases, Jg. 112 (2021-11-01), Heft 25-34, S. 25-34 |
Veröffentlichung: | Elsevier, 2021 |
Medientyp: | academicJournal |
ISSN: | 1201-9712 (print) |
DOI: | 10.1016/j.ijid.2021.08.062 |
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