Effect of immune modulation in relapsed peripheral T-cell lymphomas after post-allogeneic stem cell transplantation: a study by the Société Française de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC)
In: ISSN: 0268-3369 ; Bone Marrow Transplantation ; https://univ-rennes.hal.science/hal-01299298 ; Bone Marrow Transplantation, 2016, 51 (3), pp.358--364. ⟨10.1038/bmt.2015.280⟩, 2016
academicJournal
Zugriff:
International audience ; Peripheral T-cell lymphoma carries a poor prognosis. To document a possible graft-versus-lymphoma effect in this setting, we evaluated the impact of immunomodulation in 63 patients with peripheral T-cell lymphoma who relapsed after allogeneic transplant in 27 SFGM-TC centers. Relapse occurred after a median of 2.8 months. Patients were then treated with non-immunologic strategies (chemotherapy, radiotherapy) and/or immune modulation (donor lymphocyte infusions (DLI) and/or discontinuation of immunosuppressive therapy). Median overall survival (OS) after relapse was 6.1 months (DLI group: 23.6 months, non-DLI group: 3.6 months). Among the 14 patients who received DLI, 9 responded and 2 had stable disease. Among the remaining 49 patients, a complete response accompanied by extensive chronic GvHD was achieved in two patients after tapering of immunosuppressive drugs. Thirty patients received radio-chemotherapy, with an overall response rate of 50%. In multivariate analysis, chronic GvHD (odds ratio: 11.25 (2.68–48.21), P=0.0009) and skin relapse (odds ratio: 4.15 (1.04–16.50), P=0.043) were associated with a better response to treatment at relapse. In a time-dependent analysis, the only factor predictive of OS was the time from transplantation to relapse (hazards ratio: 0.33 (0.17–0.640), P=0.0009). This large series provides encouraging evidence of a true GvL effect in this disease
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Effect of immune modulation in relapsed peripheral T-cell lymphomas after post-allogeneic stem cell transplantation: a study by the Société Française de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC)
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Autor/in / Beteiligte Person: | Mamez, A. C. ; Levy, V. ; Chevallier, P. ; Blaise, D. ; Vigouroux, S. ; Xhaard, A. ; Fegueux, N. ; Contentin, N. ; Beguin, Y. ; Ifrah, N. ; Bulabois, C. E. ; Suarez, F. ; Yakoub-Agha, I. ; Turlure, P. ; Deconink, E. ; Lamy, T. ; Cahn, J. Y. ; Huynh, A. ; Maury, S. ; Fornecker, L. M. ; Ouzegdouh, M. ; Bay, J. O. ; Guillerm, G. ; Maillard, N. ; Michallet, M. ; Malfuson, J. V. ; Bourhis, J. H. ; Rialland, F. ; Oumedaly, R. ; Jubert, C. ; Leblond, V. ; Boubaya, M. ; Mohty, M. ; Nguyen, Son ; Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes) ; Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille) ; Service d'Hématologie clinique et thérapie cellulaire CHU Limoges ; Limoges, CHU ; TheREx ; Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG) ; Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS) ; CHRU Brest - Service d'Hématologie (CHU-Brest-Hemato) ; Centre Hospitalier Régional Universitaire de Brest (CHRU Brest) ; Service d'hématologie Hôpital Edouard Herriot -, HCL ; Hôpital Edouard Herriot CHU -, HCL ; Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL) ; Hématologie ; Département de médecine oncologique Gustave Roussy ; Institut Gustave Roussy (IGR)-Institut Gustave Roussy (IGR) ; Centre d'investigation clinique en cancérologie (CI2C) ; CHU Pitié-Salpêtrière AP-HP ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU) |
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Zeitschrift: | ISSN: 0268-3369 ; Bone Marrow Transplantation ; https://univ-rennes.hal.science/hal-01299298 ; Bone Marrow Transplantation, 2016, 51 (3), pp.358--364. ⟨10.1038/bmt.2015.280⟩, 2016 |
Veröffentlichung: | HAL CCSD ; Nature Publishing Group, 2016 |
Medientyp: | academicJournal |
DOI: | 10.1038/bmt.2015.280 |
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