TBK1 Kinase Addiction in Lung Cancer Cells Is Mediated via Autophagy of Tax1bp1/Ndp52 and Non-Canonical NF-κB Signalling
Public Library of Science, 2012
academicJournal
Zugriff:
K-Ras dependent non-small cell lung cancer (NSCLC) cells are ‘addicted’ to basal autophagy that reprograms cellular metabolism in a lysosomal-sensitive manner. Here we demonstrate that the xenophagy-associated kinase TBK1 drives basal autophagy, consistent with its known requirement in K-Ras-dependent NSCLC proliferation. Furthermore, basal autophagy in this context is characterised by sequestration of the xenophagy cargo receptor Ndp52 and its paralogue Tax1bp1, which we demonstrate here to be a bona fide cargo receptor. Autophagy of these cargo receptors promotes non-canonical NF-κB signalling. We propose that this TBK1-dependent mechanism for NF-κB signalling contributes to autophagy addiction in K-Ras driven NSCLC.
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TBK1 Kinase Addiction in Lung Cancer Cells Is Mediated via Autophagy of Tax1bp1/Ndp52 and Non-Canonical NF-κB Signalling
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Autor/in / Beteiligte Person: | Newman, Alice C. ; Scholefield, Caroline L. ; Kemp, Alain J. ; Newman, Michelle ; McIver, Edward G. ; Kamal, Ahmad ; Wilkinson, Simon |
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Veröffentlichung: | Public Library of Science, 2012 |
Medientyp: | academicJournal |
DOI: | 10.1371/journal.pone.0050672 |
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