Copy number variations in DCC/ 18q and ERBB2/ 17q are associated with disease-free survival in microsatellite stable colon cancer
In: ISSN: 0020-7136, 2017
academicJournal
Zugriff:
IF 5.531 ; International audience ; We conducted a prospective study to assess the prognostic impact of selected copy number variations (CNVs) in stage II-III microsatellite stable (MSS) colon cancer. A total of 401 patients were included from 01/2004 to 01/2009. The CNVs in 8 selected target genes, DCC/18q, EGFR/7p, TP53/17p, BLK/8p, MYC/8q, APC/5q, ERBB2/17q, and STK6/20q, were detected using a quantitative multiplex polymerase chain reaction of short fluorescent fragment (QMPSF) method. The primary end-point was the impact of the CNVs on the 4-year disease-free survival (DFS). The recurrence rate at 4 years was 20.9%, corresponding to 14% stage II patients vs 31% stage III patients (p<0.0001). The 4-year DFS was significantly decreased in patients with a loss at DCC/18q (p=0.012) and a gain at ERBB2/17q (p=0.041). The multivariate analysis demonstrated that stage III, a loss at DCC/18q and a gain at ERBB2/17q were independent factors associated with DFS. A combination of DCC/18q and ERBB2/17q was also associated with relapse, with the hazard ratio increasing from 1 to 2.4 (95% confidence interval (CI), 1.5-4.1) and 3.1 (95% CI, 1.2-8.4) in the presence of 0, 1, or 2 alterations, respectively (p=0.0013). CNVs in DCC/18q and ERBB2/17q are significantly associated with DFS in stage II-III MSS colon cancer. This article is protected by copyright. All rights reserved.
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Copy number variations in DCC/ 18q and ERBB2/ 17q are associated with disease-free survival in microsatellite stable colon cancer
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| Autor/in / Beteiligte Person: | Sefrioui, David ; Vermeulin, Thomas ; Blanchard, France ; Chapusot, Caroline ; Beaussire, Ludivine ; Armengol-Debeir, Laura ; Sesboüé, Richard ; Gangloff, Alice ; Hebbar, Mohamed ; Copin, Marie-Christine ; Houivet, Estelle ; Schwarz, Lilian ; Clatot, Florian ; Tuech, Jean-Jacques ; Bénichou, Jacques ; Martin, Laurent ; Bouvier, Anne-Marie ; Sabourin, Jean-Christophe ; Sarafan-Vasseur, Nasrin ; Frébourg, Thierry ; Lepage, Côme ; Michel, Pierre ; Di Fiore, Frédéric ; Génétique du cancer et des maladies neuropsychiatriques (GMFC) ; Université de Rouen Normandie (UNIROUEN) ; Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM) ; Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques (GPMCND) ; Hôpital Charles Nicolle Tunis ; Service de génétique Rouen ; Rouen, CHU ; Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN) ; Normandie Université (NU) ; Lipides - Nutrition - Cancer (U866) (LNC) ; Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon (ENSBANA) ; Service d'Hépato-Gastroentérologie CHU Rouen ; Hôpital Charles Nicolle Rouen ; Normandie Université (NU)-Normandie Université (NU)-CHU Rouen ; Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille) ; Service de pathologie CHU Lille ; Normandie Université (NU)-Normandie Université (NU) ; Groupe d'étude des proliférations lymphoïdes (GPL) ; Unité de Biostatistiques CHU Rouen ; Centre Guillaume le Conquérant ; Centre de radiothérapie Guillaume le Conquérant (CGLC) ; Service d'Anatomie et Cytologie Pathologique CHU Rouen ; Département d'oncologie médicale Rouen ; Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen (CLCC Henri Becquerel) |
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| Zeitschrift: | ISSN: 0020-7136, 2017 |
| Veröffentlichung: | HAL CCSD ; Wiley, 2017 |
| Medientyp: | academicJournal |
| DOI: | 10.1002/ijc.30584 |
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