An automated pipeline for Centiloid quantification of amyloid‐β using multiple 11 C‐PiB‐PET and 18 F‐PET tracers
In: Alzheimer's & Dementia ; volume 19, issue S16 ; ISSN 1552-5260 1552-5279, 2023
academicJournal
Zugriff:
Background Quantitative measures of amyloid‐β (Aβ) pathology using positron emission tomography (PET) imaging are sensitive to identify pathological changes early in Alzheimer’s disease (AD). The Centiloid scale aims to standardize these in vivo amyloid quantifications to a 100‐point scale, where an average value of zero signifies high certainty of amyloid negativity and 100 identifies average typical AD Aβ‐pathology load (Klunk et al., 2015). The current study developed and validated a single and fully automated Centiloid quantification pipeline for multiple amyloid PET compounds. Method QyScore’s® fully automated pipeline was validated on 11 C‐PiB‐PET and 18 F‐PET images from the Centiloid project (https://www.gaain.org/centiloid‐project): 34 young controls [age = 31.5 ± 6.3 years] and 47 AD patients [age = 67.5 ± 10.5 years; CDR = 0.5–1]. 18 F tracers included Florbetapir (FBP, N = 46), Forbetaben (FBB, N = 35), Flutemetamol (FTM, N = 74) and NAV4694 (NAV, N = 55). PET/MR image pairs were both co‐registered and normalized in the MNI template space. The fully automated segmentation from QyScore®, a CE‐marked and FDA‐cleared neuroimaging medical device, parcellated the masks of the grey matter tissue (target) and of the cerebellum (reference) region (Figure 1). The standardized uptake value ratio (SUVr) was computed as the ratio of the mean signal in both regions. Correlations of 11 C‐PiB‐PET and 18 F‐PET SUVr values with published SUVr data were computed. Further, correlations between 18 F‐PET SUVr and paired 11 C‐PiB‐PET SUVr were computed. Correlation coefficients (R 2 ) > 0.7 were required to consider the Centiloid calibration valid. Result QyScore’s® fully automated quantitative pipeline produced SUVr values well within the bounds defined by the Centiloid method (SUVr_AD‐100 = 2.08 +/‐ 0.2; SUVr_YC‐0 = 1.01+/‐ 0.05; R2 = 0.99; slope = 1.00; intercept = ‐0.44). 11C‐PiB SUVr correlation coefficients with published values were above 0.99 (Figure 2). Correlation coefficients of 18 F‐PET SUVr with ...
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An automated pipeline for Centiloid quantification of amyloid‐β using multiple 11 C‐PiB‐PET and 18 F‐PET tracers
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Autor/in / Beteiligte Person: | Gordon, Elizabeth ; Borrot, Mathilde ; Gueddou, Ayoub ; Jubault, Thomas ; Guizard, Nicolas |
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Zeitschrift: | Alzheimer's & Dementia ; volume 19, issue S16 ; ISSN 1552-5260 1552-5279, 2023 |
Veröffentlichung: | Wiley, 2023 |
Medientyp: | academicJournal |
DOI: | 10.1002/alz.080228 |
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