Anti-Cancer and Radio-Sensitizing Properties of New Bimetallic ( N -Heterocyclic Carbene)-Amine-Pt(II) Complexes
In: ISSN: 0022-2623, 2023
Online
academicJournal
Zugriff:
International audience ; Bioactive NHC-transition metal complexes have shown promise as anti-cancer agents, but their potential use as radiosensitizers has been neglected so far. We disclose here a new series of bimetallic platinum(II) complexes displaying NHC-type bridging ligands, (bis-NHC)[trans-Pt(RNH2)I2]2 that have been synthesized via a simple, two-step procedure. They display cytotoxicity in the micromolar range on cancerous cell lines, accumulate in cells and bind to genomic DNA, by inducing DNA damages. Notably, these bimetallic complexes demonstrate significant radiosensitizing effects on both ovarian cells A2780 and non-small lung carcinoma cells H1299. Further investigations revealed that bimetallic species make irradiation-induced DNA damages more persistent by inhibiting repair mechanisms. Indeed, a higher and persistent accumulation of both -H2AX and 53BP1 foci post-irradiation was detected, in the presence of the NHC-Pt complexes. Overall, we provide the first in vitro evidence for the radiosensitizing properties of NHC-platinum complexes, that suggests their potential use in combined chemo-radio therapy protocols.
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Anti-Cancer and Radio-Sensitizing Properties of New Bimetallic ( N -Heterocyclic Carbene)-Amine-Pt(II) Complexes
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Autor/in / Beteiligte Person: | Jia, Tao ; Diane, Oumar ; Ghosh, Deepanjan ; Skander, Myriem ; Fontaine, Gaelle ; Retailleau, Pascal ; Poupon, Joël ; Bignon, Jérôme ; Moulai Siasia, Ytabelle Maga ; Servajean, Vincent ; Hue, Nathalie ; Betzer, Jean-François ; Marinetti, Angela ; Bombard, Sophie ; Chimie et modélisation pour la biologie du cancer (CMBC) ; Institut Curie Paris -Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS) ; Institut de Chimie des Substances Naturelles (ICSN) ; Institut de Chimie du CNRS (INC)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS) ; Laboratoire de Toxicologie Biologique, Hôpital Lariboisière ; Hôpital Lariboisière-Fernand-Widal, APHP ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP) ; European Project: 666003,H2020,H2020-MSCA-COFUND-2014,IC-3i-PhD(2016) |
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Zeitschrift: | ISSN: 0022-2623, 2023 |
Veröffentlichung: | HAL CCSD ; American Chemical Society, 2023 |
Medientyp: | academicJournal |
DOI: | 10.1021/acs.jmedchem.3c00267 |
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