Major discrepancy between factual antibiotic resistance and consumption in South of France: analysis of 539,037 bacterial strains
In: ISSN: 2045-2322, 2020
academicJournal
Zugriff:
International audience ; The burden of antibiotic resistance is currently estimated by mathematical modeling, without real count of resistance to key antibiotics. Here we report the real rate of resistance to key antibiotics in bacteria isolated from humans during a 5 years period in a large area in southeast in France. We conducted a retrospective study on antibiotic susceptibility of 539,107 clinical strains isolated from hospital and private laboratories in south of France area from January 2014 to January 2019. The resistance rate to key antibiotics as well as the proportion of bacteria classified as Difficult-to-Treat (DTR) were determined and compared with the Mann-Whitney U test, the chi(2) test or the Fisher's exact test. Among 539,037 isolates, we did not observe any significant increase or decrease in resistance to key antibiotics for 5 years, (oxacillin resistance in Staphylococcus aureus, carbapenem resistance in enterobacteria and Pseudomonas aeruginosa and 3rd generation cephalosporin resistance in Escherichia coli and Klebsiella pneumoniae). However, we observed a significant decrease in imipenem resistance for Acinetobacter baumannii from 2014 to 2018 (24.19-12.27%; p = 0.005) and a significant increase of ceftriaxone resistance in Klebsiella pneumoniae (9.9-24.03%; p = 0.001) and Enterobacter cloacae (24.05-42.05%; p = 0.004). Of these 539,037 isolates, 1604 (0.3%) had a DTR phenotype. Over a 5-year period, we did not observe a burden of AR in our region despite a high rate of antibiotic consumption in our country. These results highlight the need for implementation of real-time AR surveillance systems which use factual data.
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Major discrepancy between factual antibiotic resistance and consumption in South of France: analysis of 539,037 bacterial strains
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Autor/in / Beteiligte Person: | Diallo, Ousmane Oumou ; Baron, Sophie Alexandra ; Dubourg, Gregory ; Chaudet, Herve ; Halfon, Philippe ; Camiade, Sabine ; Comte, Beatrice ; Joubert, Stephanie ; Francois, Arnaud ; Seyral, Philippe ; Parisot, Francois ; Casalta, Jean-Paul ; Ruimy, Raymond ; Maruejouls, Christophe ; Achiardy, Jean-Christophe ; Burignat, Sophie ; Carvajal, Joseph ; Delaunay, Edouard ; Meyer, Sandra ; Levy, Pierre-Yves ; Roussellier, Patricia ; Brunet, Patrick ; Bosi, Claude ; Stolidi, Philippe ; Arzouni, Jean-Pierre ; Gay, Gisele ; Hance, Pierre ; Colson, Philippe ; Raoult, Didier ; Rolain, Jean-Marc ; Microbes évolution phylogénie et infections (MEPHI) ; Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU) ; Institut Hospitalier Universitaire Méditerranée Infection (IHU Marseille) ; Vecteurs - Infections tropicales et méditerranéennes (VITROME) ; Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées (IRBA) ; ALPHABIO - Laboratoire de biologie médicale ; Equipe de Recherche sur les Rationalités Philosophiques et les Savoirs (ERRAPHIS) ; Université Toulouse - Jean Jaurès (UT2J) ; Labazur, Eurofins ; European Organisation for the Exploitation of Meteorological Satellites (EUMETSAT) ; Centre Hospitalier Universitaire de Nice (CHU Nice) ; Hôpital de la Timone CHU - APHM (TIMONE) |
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Zeitschrift: | ISSN: 2045-2322, 2020 |
Veröffentlichung: | HAL CCSD ; Nature Publishing Group, 2020 |
Medientyp: | academicJournal |
ISSN: | 2045-2322 |
DOI: | 10.1038/s41598-020-75158-7 |
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