Effect of N-(m-bromoanilinomethyl)-p-isopropoxyphenylsuccinimide on the anticonvulsant action of four classical antiepileptic drugs in the mouse maximal electroshock-induced seizure model
In: Current Issues in Pharmacy and Medical Sciences, Jg. 27 (2014), Heft 2, S. 76-79
Online
academicJournal
Zugriff:
The purpose of this study was to determine the effects of N-(m-bromoanilinomethyl)- p-isopropoxyphenylsuccinimide (BAM-IPPS - a new succinimide derivative) on the protective action of four classical antiepileptic drugs (AEDs: carbamazepine [CBZ], phenobarbital [PB], phenytoin [PHT] and valproate [VPA]) in the mouse maximal electroshock (MES)-induced tonic seizure model. Tonic hind limb extension (seizure activity) was evoked in adult male albino Swiss mice by a current (sine-wave, 25 mA, 500 V, 50 Hz, 0.2 s stimulus duration) delivered via ear-clip electrodes. BAM-IPPS administered (i.p.) at a dose of 150 mg/kg significantly elevated the threshold for electroconvulsions in mice (P<0.05). Lower doses of BAM-IPPS (50 and 100 mg/kg) had no significant impact on the threshold for electroconvulsions in mice. Moreover, BAM-IPPS (100 mg/kg) did not significantly affect the anticonvulsant potency of CBZ, PB, PHT and VPA in the mouse MES model. BAM-IPPS elevated the threshold for electroconvulsions in mice in a dosedependent manner. However, BAM-IPPS (100 mg/kg) did not affect the anticonvulsant action of various classical AEDs in the mouse MES model, making the combinations of BAM-IPPS with CBZ, PB, PHT and VPA neutral, from a preclinical point of view.
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Effect of N-(m-bromoanilinomethyl)-p-isopropoxyphenylsuccinimide on the anticonvulsant action of four classical antiepileptic drugs in the mouse maximal electroshock-induced seizure model
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Autor/in / Beteiligte Person: | Luszczki Jarogniew J. ; Ewa, Marzeda ; Kondrat-Wrobel Maria W. ; Daniel, Pyrka ; Kocharov Sergey L. ; Magdalena, Florek-Luszczki |
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Zeitschrift: | Current Issues in Pharmacy and Medical Sciences, Jg. 27 (2014), Heft 2, S. 76-79 |
Veröffentlichung: | Sciendo, 2014 |
Medientyp: | academicJournal |
ISSN: | 2084-980X (print) ; 2300-6676 (print) |
DOI: | 10.2478/cipms-2014-0017 |
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