Preliminary in vitro evaluation of the anti-proliferative activity of guanylhydrazone derivatives
In: EISSN: 1846-9558 ; Acta Pharmaceutica ; https://hal.science/hal-03536478 ; Acta Pharmaceutica, 2016, 66 (1), pp.129-137. ⟨10.1515/acph-2016-0015⟩ ; https://www.sciendo.com/article/10.1515/acph-2016-0015, 2016
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Zugriff:
Guanylhydrazones have shown promising antitumor activity in preclinical tumor models in several studies. In this study, we aimed at evaluating the cytotoxic eff ect of a series of synthetic guanylhydrazones. Diff erent hu-man tumor cell lines, by including HCT-8 (colon carci-noma), MDA-MB-435 (melanoma) and SF-295 (glioblas-toma) were continuous exposed to guanylhydrazone derivatives for 72 hours and growth inhibition of tumor cell lines and macrophages J774 was measured using tet-razolium salt (MTT) assay. Compounds 7, 11, 16 and 17 showed strong cytotoxic activity with IC50 values lower than 10 μmol L–1 against four tumor cell lines. Among them, 7 was less toxic to non-tumor cells. Finally, ob-tained data suggest that guanylhydrazones may be re-garded as potential lead compounds for the design of novel anticancer agents
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Preliminary in vitro evaluation of the anti-proliferative activity of guanylhydrazone derivatives
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Autor/in / Beteiligte Person: | França, Paulo H. B. ; da Silva-Júnior, Edeildo F. ; Aquino, Pedro G. V. ; Santana, Antônio E. G. ; Ferro, Jamylle N. S. ; de Oliveira Barreto, Emiliano ; Do Ó Pessoa, Cláudia ; Meira, Assuero Silva ; de Aquino, Thiago M. ; Alexandre-Moreira, Magna S. ; Schmitt, Martine ; de Araújo-Júnior, João X. ; Universidade Federal de Alagoas = Federal University of Alagoas (UFAL) ; Universidade Federal do Ceará = Federal University of Ceará (UFC) ; Laboratoire d'Innovation Thérapeutique (LIT) ; Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS) |
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Zeitschrift: | EISSN: 1846-9558 ; Acta Pharmaceutica ; https://hal.science/hal-03536478 ; Acta Pharmaceutica, 2016, 66 (1), pp.129-137. ⟨10.1515/acph-2016-0015⟩ ; https://www.sciendo.com/article/10.1515/acph-2016-0015, 2016 |
Veröffentlichung: | HAL CCSD ; Croatian Pharmaceutical Society, 2016 |
Medientyp: | academicJournal |
DOI: | 10.1515/acph-2016-0015 |
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