Genomic Epidemiology of 2015–2016 Zika Virus Outbreak in Cape Verde
In: ISSN: 1080-6040, 2020
Online
academicJournal
Zugriff:
International audience ; During 2015-2016, Cape Verde, an island nation off the coast of West Africa, experienced a Zika virus (ZIKV) outbreak involving 7,580 suspected Zika cases and 18 microcephaly cases. Analysis of the complete genomes of 3 ZIKV isolates from the outbreak indicated the strain was of the Asian (not African) lineage. The Cape Verde ZIKV sequences formed a distinct monophylogenetic group and possessed 1-2 (T659A, I756V) unique amino acid changes in the envelope protein. Phylogeographic and serologic evidence support earlier introduction of this lineage into Cape Verde, possibly from northeast Brazil, between June 2014 and August 2015, suggesting cryptic circulation of the virus before the initial wave of cases were detected in October 2015. These findings underscore the utility of genomic-scale epidemiology for outbreak investigations.
| Titel: |
Genomic Epidemiology of 2015–2016 Zika Virus Outbreak in Cape Verde
|
|---|---|
| Autor/in / Beteiligte Person: | Faye, Oumar ; de Lourdes Monteiro, Maria ; Vrancken, Bram ; Prot, Matthieu ; Lequime, Sebastian ; Diarra, Maryam ; Ndiaye, Oumar, Hamady ; Valdez, Tomas ; Tavarez, Sandra ; Ramos, Jessica ; da Veiga Leal, Silvânia ; Pires, Cecilio ; Moreira, António ; Tavares, Maria Filomena ; Fernandes, Linete ; Barreto, Jorge Noel ; Do Céu Teixeira, Maria ; de Lima Mendonça, Maria da Luz ; Gomes, Carolina Cardoso da Silva Leite ; Castellon, Mariano Salazar ; Ma, Laurence ; Lemoine, Fréderic ; Gámbaro-Roglia, Fabiana ; Delaune, Deborah ; Fall, Gamou ; Fall, Ibrahima Socé ; Diop, Mamadou ; Sakuntabhai, Anavaj ; Loucoubar, Cheikh ; Lemey, Philippe ; Holmes, Edward, C ; Faye, Ousmane ; Sall, Amadou Alpha ; Simon-Loriere, Etienne ; Institut Pasteur de Dakar ; Réseau International des Instituts Pasteur (RIIP) ; Ministry of Health Cape Verde ; Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven) ; Institut Pasteur Paris (IP) ; Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO) ; Hub Bioinformatique et Biostatistique - Bioinformatics and Biostatistics, HUB ; Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS) ; Sorbonne Université (SU) ; Université Paris-Sud - Paris 11 (UP11) ; Institut de Recherche Biomédicale des Armées Brétigny-sur-Orge (IRBA) ; Génétique fonctionnelle des maladies infectieuses - Functional Genetics of Infectious Diseases ; The University of Sydney ; This work was supported by Institut Pasteur de Dakar. P.L. received funding by the European Research Council under the European Union’s Horizon 2020 Research and Innovation Programme (grant agreement no. 725422-ReservoirDOCS) and by the Wellcome Trust through project 206298/Z/17/Z. S.L. and B.V. are supported by the Fonds Wetenschappelijk Onderzoek (Belgium). E.S.-L. received funding from the INCEPTION program (Investissements d’Avenir grant ANR-16-CONV-0005) and Institut Pasteur. F.G.-R. is part of the Pasteur-Paris University International doctoral program, BioSPC doctoral school. E.C.H. is funded by an Australian Research Council Australian Laureate Fellowship (FL170100022). ; We thank 2 anonymous reviewers whose suggestions helped to improve this manuscript ; ANR-16-CONV-0005,INCEPTION,Institut Convergences pour l'étude de l'Emergence des Pathologies au Travers des Individus et des populatiONs(2016) ; European Project: 0725422(2007) |
| Link: | |
| Zeitschrift: | ISSN: 1080-6040, 2020 |
| Veröffentlichung: | HAL CCSD ; Centers for Disease Control and Prevention, 2020 |
| Medientyp: | academicJournal |
| DOI: | 10.3201/eid2606.190928 |
| Schlagwort: |
|
| Sonstiges: |
|