Raman Thermometry Nanopipettes in Cancer Photothermal Therapy
In: Analytical Chemistry, Vol.94 No.17, pp.6463-6472; 000795715700008; 2-s2.0-85128819169; 162972
Online
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Zugriff:
Raman thermometry based on surface-enhanced Raman scattering has been developed using nanopipettes in cancer cell photothermal therapy (PTT). Gold nanorods (AuNRs) are robustly epoxied on glass pipettes with a high surface coverage of similar to 95% and less than 10 nm-wide nanogaps for intracellular thermometry and photothermal cancer therapy. The temperature changes could be estimated from the N equivalent to C band shifts of 4-fluorophenyl isocyanide (FPNC)-adsorbed AuNRs on the Raman thermometry nanopipette (RTN) surfaces. An intracellular temperature change of similar to 2.7 degrees C produced by altering the [Ca2+] in A431 cells was detected using the RTN in vitro, as checked from fura-2 acetoxymethyl ester (fura-2 AM) fluorescence images. For in vivo experiments, local temperature rises of similar to 19.2 degrees C were observed in the mouse skin, whereas infrared camera images could not tract due to spatial resolution. In addition, a tumor growth suppression was observed in the PTT processes after an administration of the three AuNR-coated nanopipettes combined with a 671 nm laser irradiation for 5 min in 30 days. These results demonstrate not only the localized temperature sensing ability of FPNC-tagged AuNR nanopipettes in cell biology but also anti-cancer effects in photothermal cancer therapy. ; N ; 1
Titel: |
Raman Thermometry Nanopipettes in Cancer Photothermal Therapy
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Autor/in / Beteiligte Person: | Dinh Nghi Ngo ; Vuong Thi Thanh Xuan Ho ; Kim, Gun ; Song, Min Seok ; Kim, Mi Ri ; Choo, Jaebum ; Joo, Sang-Woo ; Lee, So Yeong |
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Quelle: | Analytical Chemistry, Vol.94 No.17, pp.6463-6472; 000795715700008; 2-s2.0-85128819169; 162972 |
Veröffentlichung: | American Chemical Society, 2022 |
Medientyp: | academicJournal |
ISBN: | 978-0-00-795715-6 (print) ; 0-00-795715-7 (print) |
ISSN: | 0003-2700 (print) |
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